Clinic for Radiation Therapy and Special Oncology, Hannover Medical School, Hannover, Germany
Clinic for Radiation Therapy and Special Oncology, Hannover Medical School, Hannover, Germany.
In Vivo. 2022 Jan-Feb;36(1):314-324. doi: 10.21873/invivo.12704.
BACKGROUND/AIM: Post-operative radiotherapy for breast cancer can increase cardiac disease in a dose-dependent manner. In this study we show the reduction of dose to heart and left anterior descending artery (LAD) which can be achieved by using "Deep inspiration breath-hold" (DIBH) technique.
Tangential 3D-planned radiation was delivered to 357 patients with left-sided breast cancer, 159 of them with the DIBH technique. A distinction was made according to fractionation scheme.
The mean heart dose was significantly reduced by DIBH from 2.64 Gy to 1.39 Gy (p<0.001). The mean dose to the LAD was significantly reduced from 5.68 Gy to 3.88 Gy (p<0.001). Mean dose and volume receiving 5, 10 and 15 Gy of ipsilateral lung were higher with both hypofractionated schedule and conventional fractionation in the DIBH group.
DIBH in left-sided breast irradiation is an effective method of reducing the radiogenic heart dose.
背景/目的:乳腺癌术后放疗会导致心脏疾病,且剂量依赖性明显。本研究旨在展示“深吸气屏气”(DIBH)技术可降低心脏和左前降支(LAD)的剂量。
357 例左侧乳腺癌患者接受了切线 3D 计划放疗,其中 159 例采用了 DIBH 技术。根据分割方案进行了区分。
DIBH 可显著降低心脏剂量,从 2.64Gy 降至 1.39Gy(p<0.001)。LAD 平均剂量从 5.68Gy 降至 3.88Gy(p<0.001)。同侧肺 5、10 和 15Gy 的平均剂量和体积在 DIBH 组中,无论是在低分割方案还是常规分割方案中均较高。
左侧乳腺癌放疗中 DIBH 是降低放射性心脏剂量的有效方法。