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叙述性综述:放射治疗中的心脏毒性和心脏保护技术

Narrative Review: Cardiotoxicities and Cardiac-Sparing Techniques in Radiotherapy.

作者信息

Chan Maria F, Parikh Dhwani, Shi Chengyu

机构信息

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, Basking Ridge, NJ, USA.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Basking Ridge, NJ, USA.

出版信息

Technol Cancer Res Treat. 2024 Jan-Dec;23:15330338241301211. doi: 10.1177/15330338241301211.

Abstract

This review article aims to synthesize existing data on radiation-induced heart diseases in patients undergoing chest radiation therapy and also explores cardiac-sparing techniques to mitigate cardiotoxic effects. We conducted a comprehensive database search to review and consolidate data regarding chest radiotherapy and effects on the heart as well as techniques to minimize exposure to the heart. The research findings demonstrate associations between radiation exposure to cardiac substructures and subsequent cardiotoxicity. This review also stresses the importance of identifying patients at high-risk for cardiotoxicity as well as advocates for the adoption of stringent cardiac dose constraints in these patients. Advanced cardiac-sparing techniques, notably respiratory motion management, have emerged as pivotal strategies to minimize the likelihood of cardiac events. This narrative review emphasizes the critical role of these innovations in optimizing cardiac health during radiation treatment.

摘要

这篇综述文章旨在综合关于接受胸部放射治疗患者的辐射诱发心脏病的现有数据,并探索心脏保护技术以减轻心脏毒性作用。我们进行了全面的数据库检索,以回顾和整合有关胸部放疗及其对心脏的影响以及尽量减少心脏暴露的技术的数据。研究结果表明心脏亚结构的辐射暴露与随后的心脏毒性之间存在关联。本综述还强调了识别心脏毒性高危患者的重要性,并提倡对这些患者采用严格的心脏剂量限制。先进的心脏保护技术,尤其是呼吸运动管理,已成为将心脏事件发生可能性降至最低的关键策略。这篇叙述性综述强调了这些创新在优化放射治疗期间心脏健康方面的关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7cb/11622324/a368eea8dd25/10.1177_15330338241301211-fig1.jpg

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