Department of Radiology and Nuclear Medicine, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany;
Medical Research Institute and Department of Radiology, Pusan National University School of Medicine, Busan, Republic of Korea.
In Vivo. 2022 Jan-Feb;36(1):398-408. doi: 10.21873/invivo.12717.
BACKGROUND/AIM: To provide data regarding relationships between quantitative dynamic contrast enhanced magnetic resonance imaging (DCE MRI) and prognostic factors in breast cancer (BC).
Data from 4 Centers (200 female patients, mean age, 51.2±11.5 years) were acquired. The following data were collected: histopathological diagnosis, tumor grade, stage, hormone receptor status, KI 67, and DCE MRI values including K (volume transfer constant), V (volume of the extravascular extracellular leakage space (EES) and K (diffusion of contrast medium from the EES back to the plasma). DCE MRI values between different groups were compared using the Mann-Whitney U-test and by the Kruskal-Wallis H test. The association between DCE MRI and Ki 67 values was calculated by the Spearman's rank correlation coefficient.
DCE MRI values of different tumor subtypes overlapped significantly. There were no statistically significant differences of DCE MRI values between different tumor grades. All DCE MRI parameters correlated with KI-67: K, r=0.44, p=0.0001; V, r=0.34, p=0.0001; K, r=0.28, p=0.002. ROC analysis identified a K threshold of 0.3 min for discrimination of tumors with low KI-67 expression (<25%) and high KI-67 expression (≥25%): sensitivity, 75.5%, specificity, 73.0%, accuracy, 74.0%, AUC, 0.78. DCE MRI values overlapped between tumors with different T and N stages.
K, K, and V cannot be used as reliable a surrogate marker for hormone receptor status, tumor stage and grade in BC. K may discriminate lesions with high and lower proliferation activity.
背景/目的：提供乳腺癌（BC）定量动态对比增强磁共振成像（DCE MRI）与预后因素之间关系的数据。
从 4 个中心（200 名女性患者，平均年龄 51.2±11.5 岁）采集数据。收集以下数据：组织病理学诊断、肿瘤分级、分期、激素受体状态、KI67 以及 DCE MRI 值，包括 K（容积转移常数）、V（血管外细胞外间隙（EES）的体积和 K（对比剂从 EES 扩散回血浆）。使用 Mann-Whitney U 检验和 Kruskal-Wallis H 检验比较不同组之间的 DCE MRI 值。用 Spearman 秩相关系数计算 DCE MRI 值与 Ki67 值之间的相关性。
不同肿瘤亚型的 DCE MRI 值显著重叠。不同肿瘤分级之间的 DCE MRI 值没有统计学差异。所有 DCE MRI 参数均与 Ki67 相关：K，r=0.44，p=0.0001；V，r=0.34，p=0.0001；K，r=0.28，p=0.002。ROC 分析确定 K 值为 0.3 min，用于区分低 Ki67 表达（<25%）和高 Ki67 表达（≥25%）的肿瘤：敏感性 75.5%，特异性 73.0%，准确性 74.0%，AUC 0.78。不同 T 和 N 期肿瘤之间的 DCE MRI 值重叠。
K、K 和 V 不能作为 BC 中激素受体状态、肿瘤分期和分级的可靠替代标志物。K 可区分增殖活性高和低的病变。
