从荚膜组织胞浆菌细胞外囊泡研究中吸取的经验教训。

Lessons Learned from Studying Histoplasma capsulatum Extracellular Vesicles.

机构信息

Albert Einstein College of Medicine, Bronx, NY, USA.

Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil.

出版信息

Curr Top Microbiol Immunol. 2021;432:13-18. doi: 10.1007/978-3-030-83391-6_2.

DOI:10.1007/978-3-030-83391-6_2

PMID:34972874

Abstract

Histoplasma capsulatum is a major endemic mycosis. Our laboratories have demonstrated that H. capsulatum produces extracellular vesicles (EV) that are loaded with diverse compounds that influence virulence. We have further shown that H. capsulatum dynamically regulates the loading and release of fungal EV in response to stimuli and growth conditions. This chapter details the current knowledge of EV biology in H. capsulatum and the impact of this information on our understanding of this important process that is closely linked to pathogenesis.

摘要

荚膜组织胞浆菌是一种主要的地方性真菌病。我们的实验室已经证明，荚膜组织胞浆菌会产生含有多种影响毒力化合物的细胞外囊泡（EV）。我们还进一步表明，荚膜组织胞浆菌会根据刺激和生长条件，动态调节真菌 EV 的加载和释放。本章详细介绍了荚膜组织胞浆菌中 EV 生物学的现有知识，以及这些信息对我们理解与发病机制密切相关的这一重要过程的影响。