Departamento de Ciências Farmacêuticas do Instituto de Ciências Ambientais, Químicas e Farmacêuticas da Universidade Federal de São Paulo, Diadema, Brazil.
Curr Top Microbiol Immunol. 2021;432:35-44. doi: 10.1007/978-3-030-83391-6_4.
Sporotrichosis is an emerging deep mycosis and a public health concern in Brazil. This mycosis is caused by the traumatic inoculation of several species of Sporothrix from nature. However, when cats transmit the disease to humans as zoonotic transmission, severe extracutaneous manifestations are observed. Therefore, effective control of the disease requires the engagement of host receptors by pathogen-derived molecules to stimulate the immune response. In this context, extracellular vesicles from Sporothrix sp contribute to intracellular communication with host cells. In addition, however, extracellular vesicles may contribute to the spread of this fungus via delivering molecules such as proteins, nucleic acids, and lipids. Thus, understanding mechanisms behind extracellular vesicles related to Sporothrix may provide us with a way to understand and identify its capacity to manipulate the host immune system and spread the infection.
孢子丝菌病是一种新兴的深部真菌病，也是巴西的公共卫生关注点。这种真菌病是由自然界中几种孢子丝菌通过创伤性接种引起的。然而，当猫作为人畜共患病传播给人类时，会观察到严重的皮肤外表现。因此，有效控制该疾病需要病原体衍生分子与宿主受体相互作用，以刺激免疫反应。在这种情况下，来自孢子丝菌的细胞外囊泡有助于与宿主细胞进行细胞内通讯。然而，细胞外囊泡也可以通过传递蛋白质、核酸和脂质等分子来促进这种真菌的传播。因此，了解与孢子丝菌相关的细胞外囊泡的机制可能为我们提供一种理解和识别其操纵宿主免疫系统和传播感染的能力的方法。
