Cleare Levi G, Zamith-Miranda Daniel, Nosanchuk Joshua D
Department of Medicine (Division of Infectious Diseases) and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Department of Medicine (Division of Infectious Diseases) and Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Clin Vaccine Immunol. 2017 Nov 6;24(11). doi: 10.1128/CVI.00221-17. Print 2017 Nov.
Heat shock proteins (Hsps) are highly conserved biomolecules that are constitutively expressed and generally upregulated in response to various stress conditions (biotic and abiotic). Hsps have diverse functions, categorizations, and classifications. Their adaptive expression in fungi indicates their significance in these diverse species, particularly in dimorphic pathogens. and species are dimorphic fungi that are the causative agents of histoplasmosis and paracoccidioidomycosis, respectively. This minireview focuses on the pathobiology of Hsps, with particular emphasis on their roles in the morphogenesis and virulence of and and the potential roles of active and passive immunization against Hsps in protection against infection with these fungi.
热休克蛋白（Hsps）是高度保守的生物分子，它们组成性表达，并且通常在响应各种应激条件（生物和非生物）时上调。Hsps具有多种功能、分类和分级。它们在真菌中的适应性表达表明了它们在这些不同物种中的重要性，特别是在双相病原体中。荚膜组织胞浆菌和副球孢子菌分别是引起组织胞浆菌病和副球孢子菌病的双相真菌。本综述聚焦于热休克蛋白的病理生物学，特别强调它们在荚膜组织胞浆菌和副球孢子菌的形态发生和毒力中的作用，以及针对热休克蛋白的主动和被动免疫在预防这些真菌感染中的潜在作用。
