COPD 患者呼出气冷凝物与呼吸困难

Exhaled Breath Condensate and Dyspnea in COPD.

机构信息

General Hospital of Corfu, Corfu, Greece.

Bioinformatics & Human Electrophysiology Laboratory, Department of Informatics, Ionian University, Corfu, Greece.

出版信息

Adv Exp Med Biol. 2021;1337:339-344. doi: 10.1007/978-3-030-78771-4_38.

DOI:10.1007/978-3-030-78771-4_38

PMID:34972922

Abstract

Chronic obstructive pulmonary disease (COPD) possesses a crucial position in the field of respiratory medicine as there are still unsolved issues in its whole spectrum. One promising tool that is believed to provide answers to various problems in COPD is the exhaled breath condensate (EBC). Its wealth due to its content mirrors the ongoing actions taking place in the lungs and especially the two processes blamed for the pathophysiology of COPD, the inflammation and the oxidative stress. Attempts to connect the products of the analysis of the EBC with the clinical manifestations of COPD such as dyspnea are scarce. Up to date research has shown a positive correlation between the elevated levels of some markers of EBC such as HO and 8-isoprostane and dyspnea, while others present ambiguous results. The severity of COPD also seems to be connected with their increase. The purpose of this chapter is to highlight these findings and present potential correlations. Further research in EBC and its association with the clinical phenotypes of COPD and especially dyspnea is necessary.

摘要

慢性阻塞性肺疾病（COPD）在呼吸医学领域具有重要地位，因为其整个谱中仍存在未解决的问题。呼气冷凝物（EBC）是一种有前途的工具，被认为可以为 COPD 中的各种问题提供答案。它的丰富性源于其内容反映了肺部正在进行的活动，特别是导致 COPD 病理生理学的两个过程，炎症和氧化应激。将 EBC 的分析产物与 COPD 的临床表现（如呼吸困难）联系起来的尝试很少。最新的研究表明，EBC 中一些标志物（如 HO 和 8-异前列腺素）的水平升高与呼吸困难呈正相关，而其他标志物的结果则存在矛盾。COPD 的严重程度似乎也与其升高有关。本章的目的是强调这些发现并提出潜在的相关性。需要进一步研究 EBC 及其与 COPD 的临床表型（尤其是呼吸困难）的关联。