Ikram M, Khattak S G, Gilani S N
J Ethnopharmacol. 1987 Mar-Apr;19(2):185-92. doi: 10.1016/0378-8741(87)90040-7.
Eight Pakistani medicinal plants were investigated for antipyretic activity in rabbits receiving subcutaneous yeast injections. Hexane- and chloroform-soluble extracts of Aconitum napellus stems, Corchorus depressus whole plant and Gmelina asiatica roots exhibited prominent oral antipyretic activity while insignificant antipyretic effects were found in the hexane- and chloroform-soluble portions of Melia azadirachta seeds, Tinospora cordifolia stems and Vitex trifolia seeds. No antipyretic actions whatsoever were produced by extracts of A. heterophyllum roots and Hedysarum alhagi aerial parts. Toxicity studies revealed no noteworthy toxic or adverse effects for any of the above plant extracts up to the highest oral doses of 1.6 g/kg except in the case of A. napellus.
对8种巴基斯坦药用植物进行了研究，以考察其对皮下注射酵母的家兔的解热活性。乌头茎、黄花捻全株和亚洲石梓根的己烷和氯仿可溶提取物表现出显著的口服解热活性，而印楝种子、心叶地锦茎和三叶牡荆种子的己烷和氯仿可溶部分的解热作用不明显。异叶升麻根和骆驼刺地上部分的提取物未产生任何解热作用。毒性研究表明，除乌头外，上述植物提取物在高达1.6 g/kg的最高口服剂量下均未显示出明显的毒性或不良反应。
