Université Paris-Saclay, Institut Galien Paris Saclay, CNRS UMR 8612, 92296 Châtenay-Malabry, France.
Université Paris-Saclay, Institut Galien Paris Saclay, CNRS UMR 8612, 92296 Châtenay-Malabry, France.
J Control Release. 2022 Feb;342:93-110. doi: 10.1016/j.jconrel.2021.12.032. Epub 2021 Dec 29.
In the drug delivery field, there is beyond doubt that the shape of micro- and nanoparticles (M&NPs) critically affects their biological fate. Herein, following an introduction describing recent technological advances for designing nonspherical M&NPs, we highlight the role of particle shape in cell capture, subcellular distribution, intracellular drug delivery, and cytotoxicity. Then, we discuss theoretical approaches for understanding the effect of particle shape on internalization by the cell membrane. Subsequently, recent advances on shape-dependent behaviors of M&NPs in the systemic circulation are detailed. In particular, the interaction of M&NPs with blood proteins, biodistribution, and circulation under flow conditions are analyzed. Finally, the hurdles and future directions for developing nonspherical M&NPs are underscored.
在药物输送领域，毫无疑问，微纳米颗粒（M&NPs）的形状会极大地影响其生物学命运。本文首先介绍了用于设计非球形 M&NPs 的最新技术进展，然后重点介绍了颗粒形状在细胞捕获、亚细胞分布、细胞内药物传递和细胞毒性方面的作用。接着，我们讨论了用于理解颗粒形状对细胞膜内化影响的理论方法。随后，详细介绍了 M&NPs 在体循环中形状依赖性行为的最新进展。特别分析了 M&NPs 与血液蛋白的相互作用、生物分布以及在流动条件下的循环。最后，强调了开发非球形 M&NPs 所面临的挑战和未来方向。
