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直流电刺激损伤大鼠脊髓诱导脊髓功能恢复

Recovery of spinal cord function induced by direct current stimulation of the injured rat spinal cord.

作者信息

Wallace M C, Tator C H, Piper I

出版信息

Neurosurgery. 1987 Jun;20(6):878-84. doi: 10.1227/00006123-198706000-00010.

Abstract

Direct current stimulation has been shown by others to enhance the regeneration of several types of tissues, including nervous tissue in some species. The purpose of the present experiment was to assess the value of direct current stimulation for enhancing the recovery of spinal cord function after clip compression injury of the rat spinal cord. Twenty Wistar rats underwent a 1-minute, 50-g clip compression injury at T-1, after which electrodes were placed epidurally with the anode proximal and the cathode distal to the injury site. These electrodes were attached to a stimulator implanted subcutaneously. Ten animals received stimulators that produced a constant current of 14 microA, and the remainder received stimulators with no electrical output and served as controls. Assignment of stimulators was random, and the treatment group was not identified until sacrifice. Neurological function was tested weekly for 15 weeks by the inclined plane technique, after which the animals were killed and the injured cords were examined for histological evidence of regeneration. The mean inclined plane result for the treatment group (39 +/- 5 degrees) was significantly better than that for the control group (31 +/- 6 degrees) (P less than 0.02), although there was no significant difference in histological findings between the two groups. Thus, direct current stimulation of the injured mammalian spinal cord produced improvement in neurological function and warrants further investigation.

摘要

其他人已表明,直流刺激可促进多种组织的再生,包括某些物种的神经组织。本实验的目的是评估直流刺激对大鼠脊髓夹伤后促进脊髓功能恢复的价值。20只Wistar大鼠在T-1水平接受了1分钟、50克的夹伤,之后将电极置于硬膜外,阳极靠近损伤部位,阴极远离损伤部位。这些电极连接到皮下植入的刺激器上。10只动物接受能产生14微安恒定电流的刺激器,其余动物接受无电输出的刺激器并作为对照。刺激器的分配是随机的,直到处死动物时才确定治疗组。用斜面技术每周测试神经功能,持续15周,之后处死动物,检查损伤的脊髓,以寻找再生的组织学证据。治疗组的平均斜面结果(39±5度)明显优于对照组(31±6度)(P<0.02),尽管两组在组织学结果上无显著差异。因此,对损伤的哺乳动物脊髓进行直流刺激可改善神经功能,值得进一步研究。

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