Matter Lukas, Harland Bruce, Raos Brad, Svirskis Darren, Asplund Maria
School of Pharmacy, The University of Auckland, NZ 1023 Auckland, New Zealand.
APL Bioeng. 2023 Sep 19;7(3):031505. doi: 10.1063/5.0152669. eCollection 2023 Sep.
Electrical stimulation (ES) shows promise as a therapy to promote recovery and regeneration after spinal cord injury. ES therapy establishes beneficial electric fields (EFs) and has been investigated in numerous studies, which date back nearly a century. In this review, we discuss the various engineering approaches available to generate regenerative EFs through direct current electrical stimulation and very low frequency electrical stimulation. We highlight the electrode-tissue interface, which is important for the appropriate choice of electrode material and stimulator circuitry. We discuss how to best estimate and control the generated field, which is an important measure for comparability of studies. Finally, we assess the methods used in these studies to measure functional recovery after the injury and treatment. This work reviews studies in the field of ES therapy with the goal of supporting decisions regarding best stimulation strategy and recovery assessment for future work.
电刺激（ES）作为一种促进脊髓损伤后恢复和再生的疗法显示出前景。电刺激疗法可建立有益的电场（EFs），并且在许多可追溯到近一个世纪前的研究中都有涉及。在这篇综述中，我们讨论了通过直流电刺激和极低频电刺激产生再生电场的各种工程方法。我们强调了电极 - 组织界面，这对于电极材料和刺激器电路的适当选择很重要。我们讨论了如何最好地估计和控制所产生的电场，这是研究可比性的一项重要指标。最后，我们评估这些研究中用于测量损伤和治疗后功能恢复的方法。这项工作回顾了电刺激疗法领域的研究，目的是为未来工作中关于最佳刺激策略和恢复评估的决策提供支持。
