Department of Clinical Neurophysiology, Stichting Epilepsie Instellingen Nederland.
Department of Clinical Neurophysiology, Stichting Epilepsie Instellingen Nederland.
Seizure. 2022 Feb;95:33-37. doi: 10.1016/j.seizure.2021.12.012. Epub 2021 Dec 26.
We assessed three commercial automated spike detection software packages (Persyst, Encevis and BESA) to see which had the best performance.
Thirty prolonged EEG records from people aged at least 16 years were collected and 30-minute representative epochs were selected. Interictal epileptiform discharges (IEDs) were marked by three human experts and by all three software packages. For each 30-minutes selection and for each 10-second epoch we measured whether or not IEDs had occurred. We defined the gold standard as the combined detections of the experts. Kappa scores, sensitivity and specificity were estimated for each software package.
Sensitivity for Persyst in the default setting was 95% for 30-minute selections and 82% for 10-second epochs. Sensitivity for Encevis was 86% (30-minute selections) and 61% (10-second epochs). The specificity for both packages was 88% for 30-minute selections and 96%-99% for the 10-second epochs. Interrater agreement between Persyst and Encevis and the experts was similar than between experts (0.67-0.83 versus 0.63-0.67). Sensitivity for BESA was 40% and specificity 100%. Interrater agreement (0.25) was low.
IED detection by the Persyst automated software is better than the Encevis and BESA packages, and similar to human review, when reviewing 30-minute selections and 10-second epochs. This findings may help prospective users choose a software package.
我们评估了三种商业自动化尖峰检测软件包（Persyst、Encevis 和 BESA），以了解哪种软件包性能最佳。
收集了至少 16 岁的 30 份长时间脑电图记录，并选择了 30 分钟的代表性时段。由三位人类专家和所有三个软件包标记发作间期癫痫样放电（IEDs）。对于每个 30 分钟的选择和每个 10 秒的时段，我们都测量了是否发生了 IEDs。我们将专家的联合检测定义为金标准。为每个软件包估计了 Kappa 评分、灵敏度和特异性。
在默认设置下，Persyst 的灵敏度为 95%，用于 30 分钟的选择，82%用于 10 秒的时段。Encevis 的灵敏度为 86%（30 分钟的选择）和 61%（10 秒的时段）。这两个软件包的特异性均为 88%，用于 30 分钟的选择，96%-99%用于 10 秒的时段。Persyst 和 Encevis 与专家之间的组内一致性与专家之间的相似（0.67-0.83 与 0.63-0.67）。BESA 的灵敏度为 40%，特异性为 100%。组内一致性（0.25）较低。
在审查 30 分钟的选择和 10 秒的时段时，Persyst 自动化软件检测 IED 的性能优于 Encevis 和 BESA 软件包，与人工审查相似。这些发现可能有助于潜在用户选择软件包。
