Maksimova N M, Sukhorukova N L, Finkel' M P
Zh Mikrobiol Epidemiol Immunobiol. 1987 May(5):50-4.
The present article deals with the data on the duration of antidiphtheria immunity, induced by the primary cycle of immunization with adsorbed DPT vaccine, with the aim of considering the problems of optimizing the immunization schedule for children. The prolongation of the interval before the second booster immunization to 7-10 years produces no negative influence on the effectiveness of immunization. Besides, the study has shown that after the main complex of immunizations with adsorbed DPT vaccine protective immunity to diphtheria is retained in 90.3-96.8% of children covered by this study for 9-10 years. These data point to high immunological effectiveness of adsorbed DPT vaccine and to the possibility of prolonging the intervals between booster immunizations to 10 years, as well as decreasing the number of booster immunizations in the immunization schedule for children.
本文论述了吸附百白破疫苗初次免疫周期所诱导的抗白喉免疫力持续时间的数据，目的是探讨优化儿童免疫程序的问题。将第二次加强免疫前的间隔延长至7至10年，对免疫效果没有负面影响。此外，研究表明，在接受吸附百白破疫苗主要免疫程序后，本研究涵盖的儿童中有90.3%至96.8%对白喉保持保护性免疫力达9至10年。这些数据表明吸附百白破疫苗具有很高的免疫效力，并且有可能将加强免疫的间隔延长至10年，同时减少儿童免疫程序中加强免疫的次数。
