Kriukov V I, Bolotovskiĭ V M, Mikheeva I V, Zakharova T R, Basova N N, Ruut Iu K, Iurevits L V, Adamenko R G, Raupov B E
Zh Mikrobiol Epidemiol Immunobiol. 1994 May-Jun(3):57-61.
The extensive use of adsorbed diphtheria-tetanus toxoid with reduced antigen content was found to be ineffective in the prophylaxis of diphtheria: 86.3% of diphtheria patients among those who had been immunized with this preparation fell only a year after the first booster immunization, and the proportion of those who proved to be unprotected against diphtheria on years 3, 4 and 5 after immunization reached, respectively, 21.0%, 35.5% and 49.4%. The number of children immunized with this preparation at common preschool institutions may reach 50% and more, and with an increase in the coverage of children with immunization from 10% to 50% the proportion of unprotected children may rise from 7.4% to 17.8%. The proportion of preschool institutions, insufficiently protected from diphtheria and, as a consequence, running a considerable risk of becoming (in case of the penetration of this infection) the foci of diphtheria, was found to reach 32.9%.
在接受这种制剂免疫的人群中，86.3%的白喉患者仅在首次加强免疫后一年就发病，在免疫后第3年、第4年和第5年未受白喉保护的比例分别达到21.0%、35.5%和49.4%。在普通学前机构接受这种制剂免疫的儿童数量可能达到50%及以上，随着儿童免疫覆盖率从10%提高到50%，未受保护儿童的比例可能从7.4%上升到17.8%。发现对白喉防护不足、因而（在这种感染传入的情况下）有相当大风险成为白喉病灶的学前机构比例达到32.9%。
