Qian Kai, Fu Dan, Jiang Baorui, Wang Yue, Tian Fei, Song Li, Li Lei
Department of Cardiology, Institute of Cardiovascular Development and Translational Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Medical College of YiChun University, Yichun, China.
Front Pharmacol. 2021 Dec 15;12:808144. doi: 10.3389/fphar.2021.808144. eCollection 2021.
Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still unclear. In this work, the potential active components and mechanism of Hedyotis diffusa in the treatment of cervical cancer were explored by means of network pharmacology. By constructing its active ingredient-target network, and enriching and analyzing the targets, we found the key targets and their effective components (beta-Sitosterol and Quercetin) that play a therapeutic role. Finally, we evaluated the prognostic value of the core target genes through survival analysis. Our work initially explored the therapeutic mechanism of cervical cancer, which lays a theoretical foundation for further exploring its pharmacological action and its clinical application.
宫颈癌是全球女性中最常见的恶性肿瘤之一。在临床实践中，白花蛇舌草在治疗宫颈癌方面具有药理作用，但其成分相对复杂，白花蛇舌草治疗宫颈癌的机制仍不清楚。在这项工作中，通过网络药理学方法探索了白花蛇舌草治疗宫颈癌的潜在活性成分和机制。通过构建其活性成分-靶点网络，并对靶点进行富集和分析，我们发现了发挥治疗作用的关键靶点及其有效成分（β-谷甾醇和槲皮素）。最后，我们通过生存分析评估了核心靶基因的预后价值。我们的工作初步探索了宫颈癌的治疗机制，为进一步探索其药理作用及其临床应用奠定了理论基础。
