Benn Gregory, Adidam Sneha, Ali Ahmed, Taddesse-Heath Lekidelu
Internal Medicine, Howard University Hospital, Washington, USA.
Oncology, Howard University Hospital, Washington, USA.
Cureus. 2021 Nov 24;13(11):e19854. doi: 10.7759/cureus.19854. eCollection 2021 Nov.
Hodgkin's Lymphoma presenting with hypereosinophilia and intractable pruritus is a rare entity. Diagnostic and therapeutic decisions remain a challenge in such patients. Here we report a case of a 25-year-old female with a special case of Hodgkin's lymphoma. A 25-year-old was admitted to our hospital for intractable pruritus and was found to have significant leukocytosis with eosinophilic predominance. The patient underwent a bone marrow biopsy and mediastinal lymph node biopsy, which confirmed classical Hodgkin's lymphoma. Furthermore, the patient was given six cycles of adriamycin, bleomycin, vincristine, and doxorubicin (ABVD) chemotherapy and initially showed improvement; however, she relapsed within a short period. Post-treatment positron emission tomography (PET) scan showed interval progression of the disease, and so the patient was referred for a clinical trial with immunotherapy and Brentuximab vedotin.
以嗜酸性粒细胞增多和顽固性瘙痒为表现的霍奇金淋巴瘤是一种罕见的疾病。对于这类患者，诊断和治疗决策仍然是一项挑战。在此，我们报告一例25岁女性的特殊霍奇金淋巴瘤病例。一名25岁女性因顽固性瘙痒入院，发现有明显的白细胞增多且以嗜酸性粒细胞为主。患者接受了骨髓活检和纵隔淋巴结活检，确诊为经典型霍奇金淋巴瘤。此外，患者接受了六个周期的阿霉素、博来霉素、长春新碱和多柔比星（ABVD）化疗，最初病情有所改善；然而，她在短期内复发。治疗后的正电子发射断层扫描（PET）显示疾病有进展，因此该患者被转诊至一项免疫疗法和维布妥昔单抗的临床试验。
