霍奇金病中选择性外周血嗜酸性粒细胞增多与生存优势相关（英国国家淋巴瘤研究组报告第31号）。英国国家淋巴瘤调查。
Selective peripheral blood eosinophilia associated with survival advantage in Hodgkin's disease (BNLI Report No 31). British National Lymphoma Investigation.
作者信息
Vaughan Hudson B, Linch D C, Macintyre E A, Bennett M H, MacLennan K A, Vaughan Hudson G, Jelliffe A M
出版信息
J Clin Pathol. 1987 Mar;40(3):247-50. doi: 10.1136/jcp.40.3.247.
Abstract
A peripheral blood eosinophilia was found at presentation in 193 of 1260 (15%) patients with Hodgkin's disease who had been entered into clinical studies by the British National Lymphoma Investigation (BNLI). Eosinophilia as a component of a general leucocytosis conferred no survival advantage. Eosinophilia without a general leucocytosis was present in 95 patients, and this selective eosinophilia was associated with a clear survival advantage. The association of selective eosinophilia and improved survival was limited to patients with mixed cellularity and grade I nodular sclerosis histology. Selective eosinophilia was found to be a good prognostic indicator both in local and generalised disease. Its survival advantage seemed to lie in the response to second line treatment following relapse.
摘要
在英国国家淋巴瘤研究（BNLI）纳入临床研究的1260例霍奇金病患者中，有193例（15%）在初诊时发现外周血嗜酸性粒细胞增多。嗜酸性粒细胞增多作为全血细胞增多的一部分，对生存无优势。95例患者存在无全血细胞增多的嗜酸性粒细胞增多，这种选择性嗜酸性粒细胞增多与明显的生存优势相关。选择性嗜酸性粒细胞增多与生存改善的关联仅限于混合细胞型和Ⅰ级结节硬化组织学类型的患者。在局限性和广泛性疾病中，选择性嗜酸性粒细胞增多均被发现是一个良好的预后指标。其生存优势似乎在于复发后对二线治疗的反应。
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