Aloutaibi Yaser A, Alkarim Abdulaziz S, Qumri Esraa M, Almansour Lolo A, Alghamdi Faisal T
Advanced General Dentistry, The University Dental Hospital, King Abdulaziz University, Jeddah, SAU.
Oral Biology, Faculty of Dentistry, King Abdulaziz University, Jeddah, SAU.
Cureus. 2021 Nov 24;13(11):e19864. doi: 10.7759/cureus.19864. eCollection 2021 Nov.
Previous studies have shown that endodontic infections might increase the risk of cardiovascular diseases. However, there is no conclusive evidence that endodontic infections are associated with cardiovascular diseases among individuals with cardiac conditions. This systematic review aimed to collect and evaluate the current evidence on the relationship between chronic endodontic infections and cardiovascular diseases. The PubMed, Scopus, and Web of Science databases were searched, and Google Scholar was used to retrieve relevant clinical studies within the past 10 years (2011-2021). Observational studies (prospective cohort, retrospective cohort, cross-sectional, and case-control studies), which investigated the impact of endodontic infections and apical periodontitis in individuals with cardiac conditions at risk of cardiovascular disease, in English were considered. Review papers, duplicates, animal studies, and other irrelevant studies were excluded. Four investigators independently carried out the study selection and data collection processes. Quality assessment was performed in this review. Fourteen studies with 960,652 human subjects were included in this review. No association between endodontic infections and cardiovascular diseases among individuals with cardiac conditions was noted. Most of the studies showed a moderate overall risk of bias by 57.14% (n=8). There is weak evidence regarding the association between cardiovascular diseases and chronic endodontic infections. Further longitudinal clinical studies are required to determine the association between cardiovascular diseases and endodontic infections.
以往的研究表明，牙髓感染可能会增加心血管疾病的风险。然而，尚无确凿证据表明牙髓感染与患有心脏疾病的个体的心血管疾病有关。本系统评价旨在收集和评估关于慢性牙髓感染与心血管疾病之间关系的现有证据。检索了PubMed、Scopus和Web of Science数据库，并使用谷歌学术搜索过去10年（2011 - 2021年）内的相关临床研究。纳入了以英文发表的观察性研究（前瞻性队列研究、回顾性队列研究、横断面研究和病例对照研究），这些研究调查了牙髓感染和根尖周炎对有心血管疾病风险的患有心脏疾病个体的影响。综述论文、重复研究、动物研究和其他无关研究均被排除。四名研究人员独立进行研究筛选和数据收集过程。本综述进行了质量评估。本综述纳入了14项研究，涉及960,652名受试者。未发现患有心脏疾病的个体中牙髓感染与心血管疾病之间存在关联。大多数研究显示总体偏倚风险为中度，占57.14%（n = 8）。关于心血管疾病与慢性牙髓感染之间的关联证据薄弱。需要进一步的纵向临床研究来确定心血管疾病与牙髓感染之间的关联。
