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系统性曲霉病：1例接受伊布替尼治疗的弥漫性大B细胞淋巴瘤患者的影像学表现

Systemic Aspergillosis: Radiological Findings in a Case With Diffuse Large B Cell Lymphoma Treated by Ibrutinib.

作者信息

Pehlivan Umur Anil, Onan Hasan Bilen, Bayram Ertugrul, Keser Celalet, Paydas Semra

机构信息

Radiology, Van Baskale State Hospital, Van, TUR.

Radiology, Çukurova University Faculty of Medicine, Adana, TUR.

出版信息

Cureus. 2021 Nov 26;13(11):e19911. doi: 10.7759/cureus.19911. eCollection 2021 Nov.

DOI:10.7759/cureus.19911
PMID:34976517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8712240/
Abstract

Herein, we present a case of systemic aspergillosis with a fatal outcome in a case with diffuse large B cell lymphoma (DLBCL) treated by ibrutinib. Aspergillosis was suspected clinically and proven microbiologically. Radiological findings were compatible with aspergillosis. We aim to review radiological findings in a case with DLBCL treated with ibrutinib, which is an important tyrosine kinase inhibitor used in lymphoid neoplasias.

摘要

在此，我们报告一例接受依鲁替尼治疗的弥漫性大B细胞淋巴瘤（DLBCL）患者发生的系统性曲霉病，并导致致命结局。临床上怀疑为曲霉病，微生物学检查得以证实。影像学表现与曲霉病相符。我们旨在回顾一例接受依鲁替尼治疗的DLBCL患者的影像学表现，依鲁替尼是用于淋巴样肿瘤的一种重要的酪氨酸激酶抑制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5380/8712240/bc11e51fd3dc/cureus-0013-00000019911-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5380/8712240/5a5779e55471/cureus-0013-00000019911-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5380/8712240/569ba3ebb94a/cureus-0013-00000019911-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5380/8712240/bc11e51fd3dc/cureus-0013-00000019911-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5380/8712240/5a5779e55471/cureus-0013-00000019911-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5380/8712240/569ba3ebb94a/cureus-0013-00000019911-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5380/8712240/bc11e51fd3dc/cureus-0013-00000019911-i03.jpg

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本文引用的文献

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A case of ibrutinib-associated aspergillosis presenting with central nervous system, myocardial, pulmonary, intramuscular, and subcutaneous abscesses.1例与依鲁替尼相关的曲霉病，表现为中枢神经系统、心肌、肺部、肌肉和皮下脓肿。
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Call for Action: Invasive Fungal Infections Associated With Ibrutinib and Other Small Molecule Kinase Inhibitors Targeting Immune Signaling Pathways.行动呼吁：伊布替尼和其他靶向免疫信号通路的小分子激酶抑制剂相关的侵袭性真菌感染。
Clin Infect Dis. 2018 Jan 6;66(1):140-148. doi: 10.1093/cid/cix687.
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MRI of CNS fungal infections: review of aspergillosis to histoplasmosis and everything in between.中枢神经系统真菌感染的磁共振成像：从曲霉病到组织胞浆菌病及其间所有疾病的综述
Clin Neuroradiol. 2014 Sep;24(3):217-30. doi: 10.1007/s00062-014-0305-7. Epub 2014 May 29.
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Ibrutinib for B cell malignancies.伊布替尼治疗 B 细胞恶性肿瘤。
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