Cembranel Francieli, Boing Alexandra Crispim, Boing Antonio Fernando, Xavier André Junqueira, d'Orsi Eleonora
Public Health Postgraduate Program and Department of Nutrition, Federal University of Santa Catarina, Trindade University Campus, Florianópolis, Santa Catarina 88040-900, Brazil.
Public Health Postgraduate Program, Federal University of Santa Catarina, Trindade University Campus, Florianópolis, Santa Catarina 88040-900, Brazil.
Prev Med Rep. 2021 Oct 7;24:101587. doi: 10.1016/j.pmedr.2021.101587. eCollection 2021 Dec.
To investigate the association between deficient and insufficient serum concentrations of 25(OH)D and cardiometabolic risk factors (CMRF), considering that both conditions are important predictors of cardiovascular disease and diabetes mellitus. A cross-sectional study with a subsample of 526 older adults (63-93 years old) who participated in the second wave of the population-based longitudinal study . The CMRF analyzed were abdominal obesity, high fasting glucose, high blood pressure, high triglycerides and high LDL-cholesterol. The exposure variable was 25(OH)D serum concentration (≤20 ng/mL = deficient; 21-29 ng/mL = insufficient, ≥30-<100 ng/mL = sufficient). The prevalences of 25(OH)D deficiency and insufficiency were estimated at 21.9% and 43.7%, respectively. The adjusted OR of prevalence of the abdominal obesity (OR 1.99;1.12-3.54), high blood pressure (OR 2.58;1.35-4.94) and high LDL-cholesterol (OR 2.73;1.63-4.6) were higher among those with deficient serum concentration of 25(OH)D. Participants with insufficient serum concentrations of 25(OH)D also presented higher adjusted OR of prevalence for abdominal obesity (OR 2.14;1.31-3.48). No significant adjusted association was found between 25(OH)D with the outcomes high fasting glucose and high triglycerides. Significant effect modification/interaction by age was also observed in the tested associations for abdominal obesity (P < 0.001), blood pressure (P < 0.001) and LDL-cholesterol (P < 0.001), in which deficient and insufficient 25(OH)D values were associated with higher values of these FRCM. 25(OH)D serum concentrations between 30 and 100 ng/mL can contribute to preventing and controlling CMRF such as abdominal obesity, high blood pressure and high LDL-cholesterol. The understanding this particular interaction may indicate ways to prevent/control cardiometabolic outcomes, health problems common in the older adults.
鉴于血清25(OH)D浓度缺乏和不足均为心血管疾病和糖尿病的重要预测因素，本研究旨在探讨血清25(OH)D浓度缺乏和不足与心血管代谢危险因素（CMRF）之间的关联。对参与基于人群的纵向研究第二轮的526名老年人（63 - 93岁）的子样本进行了横断面研究。所分析的CMRF包括腹型肥胖、空腹血糖高、高血压、高甘油三酯和高LDL - 胆固醇。暴露变量为血清25(OH)D浓度（≤20 ng/mL = 缺乏；21 - 29 ng/mL = 不足，≥30 - <100 ng/mL = 充足）。血清25(OH)D缺乏和不足的患病率分别估计为21.9%和43.7%。血清25(OH)D浓度缺乏者腹型肥胖（OR 1.99；1.12 - 3.54）、高血压（OR 2.58；1.35 - 4.94）和高LDL - 胆固醇（OR 2.73；1.63 - 4.6）患病率的调整后OR更高。血清25(OH)D浓度不足者腹型肥胖患病率的调整后OR也更高（OR 2.14；1.31 - 3.48）。未发现25(OH)D与空腹血糖高和高甘油三酯之间存在显著的调整后关联。在腹型肥胖（P < 0.001）、血压（P < 0.001）和LDL - 胆固醇（P < 0.001）的测试关联中也观察到年龄有显著的效应修饰/交互作用，其中25(OH)D缺乏和不足与这些心血管代谢危险因素的较高值相关。血清25(OH)D浓度在30至100 ng/mL之间有助于预防和控制腹型肥胖、高血压和高LDL - 胆固醇等心血管代谢危险因素。了解这种特殊的相互作用可能为预防/控制心血管代谢结局（老年人常见的健康问题）指明方向。
