Katsuura-Kamano Sakurako, Arisawa Kokichi, Uemura Hirokazu, Van Nguyen Tien, Takezaki Toshiro, Ibusuki Rie, Suzuki Sadao, Otani Takahiro, Okada Rieko, Kubo Yoko, Tamura Takashi, Hishida Asahi, Koyama Teruhide, Matsui Daisuke, Kuriki Kiyonori, Takashima Naoyuki, Miyagawa Naoko, Ikezaki Hiroaki, Matsumoto Yuji, Nishida Yuichiro, Shimanoe Chisato, Oze Isao, Matsuo Keitaro, Mikami Haruo, Kusakabe Miho, Takeuchi Kenji, Wakai Kenji
Department of Preventive Medicine, Tokushima University Graduate School of Biomedical Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Department of Health and Welfare System, College of Nursing Art and Science, University of Hyogo, Akashi 673-8588, Japan.
Prev Med Rep. 2021 Oct 25;24:101613. doi: 10.1016/j.pmedr.2021.101613. eCollection 2021 Dec.
The purpose of the study was to investigate sex-specific associations of skipping breakfast and short sleep duration with metabolic syndrome (MetS) and their interaction. We analyzed baseline data of 14,907 men and 14,873 women aged 35-69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study from 2005. MetS was diagnosed using a modification of the National Cholesterol Education Program Adult Treatment Panel III revised definition (NCEP-R 2005), using body mass index instead of waist circumference. Breakfast consumption was classified into two categories: ≥6 days/week (consumers) or <6 days/week (skippers). Sleep duration was classified into three categories: <6h, 6 to <8 h, and ≥8 h/day. Multivariate logistic regression analysis was performed to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) and examine the presence of interaction. In men, skipping breakfast and short sleep duration were independently associated with an increased prevalence of MetS (OR 1.26, 95%CI 1.12-1.42 and OR 1.28, 95%CI 1.12-1.45, respectively), obesity, and components of MetS. However, no significant interaction was observed between skipping breakfast and short sleep duration. In women, skipping breakfast and short sleep duration were associated with an increased prevalence of obesity, but not with MetS. These findings indicate that breakfast consumption and moderate sleep duration may be associated with a lower risk of MetS, particularly in men.
本研究的目的是调查不吃早餐和睡眠时间短与代谢综合征（MetS）之间的性别特异性关联及其相互作用。我们分析了14907名年龄在35 - 69岁的男性和14873名年龄在35 - 69岁的女性的基线数据，这些人从2005年起参与了日本多机构合作队列研究。采用对美国国家胆固醇教育计划成人治疗专家组第三次修订定义（NCEP - R 2005）的修改版来诊断MetS，使用体重指数而非腰围。早餐摄入情况分为两类：每周≥6天（食用者）或每周<6天（不吃者）。睡眠时间分为三类：<6小时、6至<8小时和≥8小时/天。进行多变量逻辑回归分析以估计比值比（OR）和95%置信区间（CI），并检验相互作用的存在。在男性中（不吃早餐和睡眠时间短）分别独立与MetS患病率增加（OR 1.26，95%CI 1.12 - 1.42和OR 1.28，95%CI 1.12 - 1.45）、肥胖及MetS的各组分相关。然而，未观察到不吃早餐和睡眠时间短之间存在显著的相互作用。在女性中，不吃早餐和睡眠时间短与肥胖患病率增加相关，但与MetS无关。这些发现表明，食用早餐和适度的睡眠时间可能与较低的MetS风险相关，尤其是在男性中。
