Feng Ziqing, Wang Gengyuan, Xia Honghui, Li Meng, Liang Guoxia, Dong Tingting, Xiao Peng, Yuan Jin
State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Department of Ophthalmology, Zhaoqing Gaoyao People's Hospital, Zhaoqing, China.
Front Med (Lausanne). 2021 Dec 15;8:778346. doi: 10.3389/fmed.2021.778346. eCollection 2021.
To characterize the sex- and age-related alterations of the macular vascular geometry in a population of healthy eyes using fundus photography. A cross-sectional study was conducted with 610 eyes from 305 healthy subjects (136 men, 169 women) who underwent fundus photography examination and was divided into four age groups (G1 with age ≤ 25 years, G2 with age 26-35 years, G3 with age 36-45 years, and G4 with age ≥ 46 years). A self-developed automated retinal vasculature analysis system allowed segmentation and separate multiparametric quantification of the macular vascular network according to the Early Treatment Diabetic Retinopathy Study (ETDRS). Vessel fractal dimension (D), vessel area rate (VAR), average vessel diameter (D), and vessel tortuosity (τ) were acquired and compared between sex and age groups. There was no significant difference between the mean age of male and female subjects (32.706 ± 10.372 and 33.494 ± 10.620, respectively, > 0.05) and the mean age of both sexes in each age group ( > 0.05). The D, VAR, and D of the inner ring, the D of the outer ring, and the D and VAR of the whole macula were significantly greater in men than women ( < 0.001, < 0.001, < 0.05, respectively). There was no significant change of τ between males and females ( > 0.05). The D, VAR, and D of the whole macula, the inner and outer rings associated negatively with age ( < 0.001), whereas the τ showed no significant association with age ( > 0.05). Comparison between age groups observed that D started to decrease from G2 compared with G1 in the inner ring ( < 0.05) and D, VAR, and D all decreased from G3 compared with the younger groups in the whole macula, inner and outer rings ( < 0.05). In the healthy subjects, macular vascular geometric parameters obtained from fundus photography showed that D, VAR, and D are related to sex and age while τ is not. The baseline values of the macular vascular geometry were also acquired for both sexes and all age groups.
利用眼底摄影技术，对健康人群中黄斑区血管几何形态的性别和年龄相关变化进行特征描述。对305名健康受试者（136名男性，169名女性）的610只眼睛进行了横断面研究，这些受试者均接受了眼底摄影检查，并被分为四个年龄组（G1组年龄≤25岁，G2组年龄26 - 35岁，G3组年龄36 - 45岁，G4组年龄≥46岁）。一个自行开发的自动化视网膜血管分析系统，能够根据早期糖尿病视网膜病变研究（ETDRS）对黄斑区血管网络进行分割和单独的多参数定量分析。获取血管分形维数（D）、血管面积率（VAR）、平均血管直径（D）和血管迂曲度（τ），并在性别和年龄组之间进行比较。男性和女性受试者的平均年龄之间无显著差异（分别为32.706±10.372和33.494±10.620，P>0.05），且各年龄组中两性的平均年龄之间也无显著差异（P>0.05）。男性内环的D、VAR和D、外环的D以及整个黄斑区的D和VAR均显著大于女性（分别为P<0.001、P<0.001、P<0.05）。男性和女性之间的τ无显著变化（P>0.05）。整个黄斑区的D、VAR和D以及内环和外环与年龄呈负相关（P<0.001），而τ与年龄无显著相关性（P>0.05）。年龄组之间的比较观察到，内环中与G1组相比，G2组的D开始降低（P<0.05），整个黄斑区、内环和外环中与较年轻组相比，G3组的D、VAR和D均降低（P<0.05）。在健康受试者中，通过眼底摄影获得的黄斑区血管几何参数表明，D、VAR和D与性别和年龄有关，而τ则无关。还获取了所有性别和年龄组的黄斑区血管几何形态的基线值。
