Tamme Reeli, Jürimäe Jaak, Mäestu Evelin, Remmel Liina, Purge Priit, Mengel Eva, Tillmann Vallo
Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.
Children's Clinic of Tartu University Hospital, Tartu, Estonia.
Bone Rep. 2021 Dec 13;16:101158. doi: 10.1016/j.bonr.2021.101158. eCollection 2022 Jun.
Inconsistent associations of leptin and adiponectin with bone mineral characteristics in puberty and adolescence have been reported. We aimed to examine the associations between leptin to adiponectin ratio (LAR) in puberty and bone mineral characteristics at the age of 18 years in healthy males.
88 white Caucasian boys were investigated at T1 (mean age 12.1 years), T2 (14.0 years) and T3 (18.0 years). Serum leptin and adiponectin were measured and LAR was calculated at T1, T2 and T3, bone mineral density (BMD) and bone mineral apparent density (BMAD) for total body and lumbar spine (LS) at T1 and T3. Spearman correlation coefficient and partial correlation analyses were used to describe the associations between mean pubertal LAR and BMD at T3.
Mean pubertal LAR was negatively correlated with both LS BMD (r = -0.23; P < 0.05) and LS BMAD at T3 (r = -0.33; P < 0.05). These associations remained significant also in partial correlation analysis after controlling for total body fat percentage, total testosterone, HOMA-IR and physical activity at T1 (r = -0.31; P < 0.05 and r = -0.41; P < 0.05 respectively).
LAR in puberty is negatively associated with lumbar spine BMD and lumbar spine BMAD at the age of 18 years.
已有报道称，瘦素和脂联素与青春期和青少年期的骨矿物质特征之间的关联并不一致。我们旨在研究健康男性青春期瘦素与脂联素比值（LAR）与18岁时骨矿物质特征之间的关联。
对88名白人高加索男孩在T1（平均年龄12.1岁）、T2（14.0岁）和T3（18.0岁）进行调查。在T1、T2和T3测量血清瘦素和脂联素，并计算LAR，在T1和T3测量全身和腰椎（LS）的骨密度（BMD）和骨矿物质表观密度（BMAD）。采用Spearman相关系数和偏相关分析来描述青春期平均LAR与T3时BMD之间的关联。
青春期平均LAR与T3时的LS BMD（r = -0.23；P < 0.05）和LS BMAD均呈负相关（r = -0.33；P < 0.05）。在控制了T1时的全身脂肪百分比、总睾酮、HOMA-IR和身体活动后，这些关联在偏相关分析中也仍然显著（分别为r = -0.31；P < 0.05和r = -0.41；P < 0.05）。
青春期的LAR与18岁时的腰椎BMD和腰椎BMAD呈负相关。
