PROFITH Research Group, Sport and Health University Research Institute, Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Faculty of Health Sciences, Isabel I University, Burgos, Spain.
Acta Paediatr. 2022 Oct;111(10):1966-1973. doi: 10.1111/apa.16456. Epub 2022 Jul 5.
Adipokines seem to play a role in bone morphogenesis, although this also depends on the mechanical forces applied to the skeleton. The aim was to assess the relationships of resting leptin and adiponectin with bone parameters and whether high muscular fitness levels affect these relationships in children with overweight or obesity.
This cross-sectional study took part from 2014 to 2016 in Granada, Spain. Participants were recruited from University Hospitals, and we also used advertisements in local media and school contacts in the city. Adipokines were analysed in plasma. Muscular fitness was assessed by one repetition maximum in bench and leg press tests. Dual-energy X-ray absorptiometry was used to measure bone parameters.
We included 84 children (10.0 ± 1.2y; 63% boys) in this analysis. Leptin was negatively associated with lumbar spine bone mineral content (β = -0.162, p = 0.053). No significant interaction was found for muscular fitness. Simple slope estimates suggested that children performing more than 133.3 kg in leg press test ameliorated the negative association between leptin and lumbar spine bone mineral content.
Leptin levels were negatively associated with lumbar spine bone mineral content in children with overweight or obesity. A high muscular fitness at the lower body could counteract this association.
脂肪因子似乎在骨形态发生中发挥作用，尽管这也取决于作用于骨骼的机械力。本研究旨在评估静息状态下瘦素和脂联素与骨参数的关系，以及高肌肉健康水平是否会影响超重或肥胖儿童的这些关系。
本横断面研究于 2014 年至 2016 年在西班牙格拉纳达进行。参与者从大学医院招募，我们还在当地媒体上发布广告，并通过城市学校联系招募参与者。在血浆中分析脂肪因子。肌肉健康状况通过卧推和腿举测试的一次重复最大测试进行评估。双能 X 线吸收法用于测量骨参数。
本分析纳入了 84 名儿童（10.0±1.2 岁；63%为男性）。瘦素与腰椎骨矿物质含量呈负相关（β=-0.162，p=0.053）。未发现肌肉健康状况的显著交互作用。简单斜率估计表明，在腿举测试中表现超过 133.3kg 的儿童可以改善瘦素与腰椎骨矿物质含量之间的负相关关系。
超重或肥胖儿童的瘦素水平与腰椎骨矿物质含量呈负相关。下肢的高肌肉健康水平可能会抵消这种关联。
