抗补体剂K-76单羧酸对大鼠实验性免疫复合物型肾小球肾炎的影响。
Effect of the anticomplementary agent, K-76 monocarboxylic acid, on experimental immune complex glomerulonephritis in rats.
作者信息
Iida H, Izumino K, Asaka M, Takata M, Mizumura Y, Sasayama S
出版信息
Clin Exp Immunol. 1987 Jan;67(1):130-4.
We examined the effect of the anticomplementary agent K-76 monocarboxylic acid (K-76COOH), which is known to inhibit C5 activity, on immune complex glomerulonephritis in rats. Bovine serum albumin (BSA) nephritis was induced in rats by subcutaneous immunization and daily intravenous administration of BSA. K-76COOH (30 mg/kg) was administered intraperitoneally twice daily for 4 weeks. It was shown that K-76COOH would significantly reduce the development of proteinuria in the early stage of BSA nephritis, but it failed to suppress proteinuria in the late stage. There was no significant difference in glomerular changes between treated animals and non-treated controls. These findings suggest that C5, and the terminal complement components may play a significant role in protein excretion in the early stage of immune complex glomerulonephritis.
我们研究了已知可抑制C5活性的抗补体剂K-76单羧酸（K-76COOH）对大鼠免疫复合物性肾小球肾炎的影响。通过皮下免疫和每日静脉注射牛血清白蛋白（BSA）诱导大鼠发生BSA肾炎。K-76COOH（30 mg/kg）每日腹腔注射两次，持续4周。结果表明，K-76COOH可显著降低BSA肾炎早期蛋白尿的发生，但在后期未能抑制蛋白尿。治疗组动物与未治疗对照组的肾小球变化无显著差异。这些发现提示，C5及补体终末成分可能在免疫复合物性肾小球肾炎早期的蛋白质排泄中起重要作用。
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