头孢唑林联合厄他培南治疗耐甲氧西林金黄色葡萄球菌菌血症的成功是否基于白细胞介素-1β的释放？
Is the Success of Cefazolin plus Ertapenem in Methicillin-Susceptible Staphylococcus aureus Bacteremia Based on Release of Interleukin-1 Beta?
机构信息
School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Division of Host-Microbe Systems & Therapeutics, Center for Immunity, Infection & Inflammation, University of California-San Diego School of Medicine, La Jolla, California, USA.
出版信息
Antimicrob Agents Chemother. 2022 Feb 15;66(2):e0216621. doi: 10.1128/aac.02166-21. Epub 2022 Jan 3.
Abstract
Cefazolin and ertapenem have been shown to be an effective salvage regimen for refractory methicillin-susceptible Staphylococcus aureus bacteremia. Our findings suggest cefazolin plus ertapenem stimulates interleukin-1β release from peripheral blood monocytes both with and without S. aureus presence. This IL-1β augmentation was primarily driven by ertapenem. These findings support further exploration of cefazolin plus ertapenem in MSSA bacteremia and may partially explain its marked potency despite modest synergy .
摘要
头孢唑林和厄他培南已被证明是治疗耐甲氧西林金黄色葡萄球菌血症的有效挽救疗法。我们的研究结果表明，头孢唑林加厄他培南刺激外周血单核细胞释放白细胞介素-1β，无论是否存在金黄色葡萄球菌。这种白细胞介素-1β的增加主要是由厄他培南驱动的。这些发现支持进一步探索头孢唑林加厄他培南在 MSSA 菌血症中的应用，并且可能部分解释了其尽管协同作用较弱但仍具有显著效力的原因。
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