万古霉素暴露与急性肾损伤结局：来自CAMERA2研究的简要情况
Vancomycin Exposure and Acute Kidney Injury Outcome: A Snapshot From the CAMERA2 Study.
作者信息
Liu Jiajun, Tong Steven Y C, Davis Joshua S, Rhodes Nathaniel J, Scheetz Marc H
机构信息
Midwestern University Chicago College of Pharmacy, Downers Grove, Illinois, USA.
Northwestern Memorial Hospital, Chicago, Illinois, USA.
出版信息
Open Forum Infect Dis. 2020 Nov 4;7(12):ofaa538. doi: 10.1093/ofid/ofaa538. eCollection 2020 Dec.
Among patients with methicillin-resistant (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased with increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for the (flu)cloxacillin group. Day 2 vancomycin AUC ≥470 mg·h/L was significantly associated with AKI, independent of (flu)cloxacillin receipt.
在一项前瞻性随机临床试验的耐甲氧西林金黄色葡萄球菌（MRSA）菌血症患者中，即使在治疗范围内，急性肾损伤（AKI）发生率也随万古霉素暴露量增加而升高。（氟）氯唑西林组发生AKI的情况更常见。万古霉素第2天的曲线下面积（AUC）≥470mg·h/L与AKI显著相关，且与是否接受（氟）氯唑西林无关。
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