Garcia-Mayea Yoelsis, Mir Cristina, Carballo Laia, Sánchez-García Almudena, Bataller Marina, LLeonart Matilde E
Biomedical Research in Cancer Stem Cells Group, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Biomedical Research in Cancer Stem Cells Group, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain; Spanish Biomedical Research Network Center in Oncology, CIBERONC, Spain.
Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188674. doi: 10.1016/j.bbcan.2021.188674. Epub 2021 Dec 31.
The tetraspanin (TSPAN) family constitutes a poorly explored family of membrane receptors involved in various physiological processes, with relevant roles in anchoring multiple proteins, acting as scaffolding proteins, and cell signaling. Recent studies have increasingly demonstrated the involvement of TSPANs in cancer. In particular, tetraspanin 1 (also known as TSPAN1, NET-1, TM4C, C4.8 or GEF) has been implicated in cell survival, proliferation and invasion. Recently, our laboratory revealed a key role of TSPAN1 in the acquired resistance of tumor cells to conventional chemotherapy (e.g., cisplatin). In this review, we summarize and discuss the latest research on the physiological mechanisms of TSPANs in cancer and, in particular, on TSPAN1 regulating resistance to chemotherapy. A model of TSPAN1 action is proposed, and the potential of targeting TSPAN1 in anticancer therapeutic strategies is discussed.
四跨膜蛋白（TSPAN）家族是一类研究较少的膜受体家族，参与多种生理过程，在锚定多种蛋白质、作为支架蛋白和细胞信号传导中发挥重要作用。最近的研究越来越多地证明了四跨膜蛋白与癌症有关。特别是，四跨膜蛋白1（也称为TSPAN1、NET-1、TM4C、C4.8或GEF）与细胞存活、增殖和侵袭有关。最近，我们实验室揭示了TSPAN1在肿瘤细胞对传统化疗（如顺铂）的获得性耐药中的关键作用。在这篇综述中，我们总结并讨论了关于四跨膜蛋白在癌症中的生理机制，特别是关于TSPAN1调节化疗耐药性的最新研究。提出了TSPAN1作用模型，并讨论了在抗癌治疗策略中靶向TSPAN1的潜力。
