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致死性和非致死性麻疹病毒感染期间大鼠脑中I类和II类移植抗原的诱导。

Induction of class I and class II transplantation antigens in rat brain during fatal and non-fatal measles virus infection.

作者信息

Olsson T, Maehlen J, Löve A, Klareskog L, Norrby E, Kristensson K

出版信息

J Neuroimmunol. 1987 Oct;16(2):215-24. doi: 10.1016/0165-5728(87)90076-2.

DOI:10.1016/0165-5728(87)90076-2
PMID:3497946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7134084/
Abstract

Measles virus induced a marked increase in the expression of MHC-coded class I and class II antigens as detected by immunostaining during both fatal and non-fatal brain infections in rats. The distribution of these molecules in the brain was much more widespread than the occurrence of viral antigen suggesting a soluble factor for their induction. In 14-day-old rats with a non-fatal infection there was a marked infiltration of T lymphocytes of 'cytotoxic/suppressor' phenotype in the brain parenchyma, whereas T 'helper' cell phenotypes mainly were located perivascularly. In brains from newborn rats with a fatal infection no or only few lymphocytes were detected.

摘要

在大鼠致命性和非致命性脑感染期间，通过免疫染色检测发现，麻疹病毒可显著增加主要组织相容性复合体（MHC）编码的Ⅰ类和Ⅱ类抗原的表达。这些分子在脑中的分布比病毒抗原的出现更为广泛，提示存在一种可诱导它们产生的可溶性因子。在14日龄非致命性感染的大鼠中，脑实质内有大量“细胞毒性/抑制性”表型的T淋巴细胞浸润，而T“辅助性”细胞表型主要位于血管周围。在新生大鼠的致命性感染脑内未检测到淋巴细胞或仅检测到少量淋巴细胞。

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本文引用的文献

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Measles virus encephalitis and retinopathy in the Wistar rat.Wistar大鼠中的麻疹病毒脑炎和视网膜病变
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Nature. 1984;310(5979):688-91. doi: 10.1038/310688a0.
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The immunopathology of experimental allergic encephalomyelitis. II. Endothelial cell Ia increases prior to inflammatory cell infiltration.实验性变应性脑脊髓炎的免疫病理学。II. 炎症细胞浸润之前内皮细胞Ia增加。
J Immunol. 1984 May;132(5):2402-7.
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Expression of Ia antigens by cultured astrocytes treated with gamma-interferon.经γ干扰素处理的培养星形胶质细胞Ia抗原的表达
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Eur J Immunol. 1984 Mar;14(3):260-7. doi: 10.1002/eji.1830140311.