Lewandowski G, Hobbs M V, Bloom F E
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037.
J Neuroimmunol. 1994 Nov;55(1):23-34. doi: 10.1016/0165-5728(94)90143-0.
Previously we reported that a lethal strain of herpes simplex virus type 2 (HSV-2) infects the brain following ocular inoculation of mice. We now demonstrate that HSV-2 mediates an unusual intracellular sequestering of class II major histocompatibility complex (MHC) antigens. With use of an RNase protection assay, we observed a selective inhibition of IFN-gamma and IL-6 gene transcription in brains of mice infected with HSV-2. It is likely that the inhibition of cytokine gene expression was mediated through a failure to activate CD4+ lymphocytes. These data suggest that the infecting herpesvirus can influence the profile of intracerebrally produced cytokines, which in turn may determine the outcome of the infection.
此前我们报道，在对小鼠进行眼部接种后，一种致死性2型单纯疱疹病毒（HSV-2）会感染大脑。我们现在证明，HSV-2介导了II类主要组织相容性复合体（MHC）抗原异常的细胞内隔离。通过核糖核酸酶保护试验，我们观察到感染HSV-2的小鼠大脑中IFN-γ和IL-6基因转录受到选择性抑制。细胞因子基因表达的抑制很可能是由于未能激活CD4+淋巴细胞所致。这些数据表明，感染性疱疹病毒可影响脑内产生的细胞因子谱，而这反过来可能决定感染的结果。
