对原发性免疫反应受损患者的T细胞激活抗原受体介导途径进行选择性阻断。
Selective blockade of the antigen-receptor-mediated pathway of T cell activation in patients with impaired primary immune responses.
作者信息
Meuer S C, Hauer M, Kurz P, Meyer zum Büschenfelde K H, Köhler H
出版信息
J Clin Invest. 1987 Sep;80(3):743-9. doi: 10.1172/JCI113129.
Abstract
We investigated impaired cellular immune responses of individuals on chronic hemodialysis by using monoclonal antibodies that trigger differential pathways of T cell activation. Reduced cellular reactivity, which exists in a high proportion of such patients, can be attributed to a failure of the monocyte population to support the process of primary T cell activation in vitro. This defect results in a lack of interleukin 2 production, which is critically dependent on a monocyte-derived signal. In contrast, T lymphocyte function was found to be physiologic. Perhaps more important, the degree of monocyte dysfunction in vitro correlated with the same patients' in vivo responses to hepatitis B vaccination. Addition of recombinant human interleukin 2 fully reconstituted their deficient immune response in vitro.
摘要
我们通过使用能触发T细胞活化不同途径的单克隆抗体，研究了慢性血液透析患者受损的细胞免疫反应。此类患者中很大一部分存在细胞反应性降低的情况，这可归因于单核细胞群体在体外无法支持原发性T细胞活化过程。这种缺陷导致白细胞介素2产生不足，而白细胞介素2的产生严重依赖单核细胞衍生的信号。相比之下，发现T淋巴细胞功能是正常的。也许更重要的是，体外单核细胞功能障碍的程度与同一患者体内对乙肝疫苗接种的反应相关。添加重组人白细胞介素2可在体外完全恢复其缺陷的免疫反应。
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