Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran.
Adv Exp Med Biol. 2021;1328:513-522. doi: 10.1007/978-3-030-73234-9_36.
The prevalence of diabetes mellitus is growing rapidly. Diabetes is the underlying cause of many metabolic and tissue dysfunctions, and, therefore, many therapeutic agents have been developed to regulate the glycemic profile. Glucagon-like peptide-1 (GLP-1) receptor agonists are a newly developed class of antidiabetic drugs that have potent hypoglycemic effects via several molecular pathways. In addition to synthetic GLP-1 receptor agonists, some evidence suggests that natural products may have modulatory effects on GLP-1 expression and secretion. In the current study, we conclude that certain herbal-based constituents, such as berberine, tea, curcumin, cinnamon, wheat, soybean, resveratrol, and gardenia, can exert an influence on GLP-1 release.
糖尿病的患病率正在迅速增长。糖尿病是许多代谢和组织功能障碍的根本原因，因此已经开发了许多治疗药物来调节血糖谱。胰高血糖素样肽-1（GLP-1）受体激动剂是一类新开发的抗糖尿病药物，通过多种分子途径具有强大的降血糖作用。除了合成的 GLP-1 受体激动剂外，一些证据表明天然产物可能对 GLP-1 的表达和分泌具有调节作用。在本研究中，我们得出结论，某些基于草药的成分，如小檗碱、茶、姜黄素、肉桂、小麦、大豆、白藜芦醇和栀子，可能会影响 GLP-1 的释放。
