Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
Riddet Institute, Massey University, Palmerston North, New Zealand.
Sci Rep. 2018 Sep 12;8(1):13679. doi: 10.1038/s41598-018-32032-x.
In the current study, we aimed to evaluate the effects of a single dose of curcumin and/or fish oil on postprandial glycaemic parameters in healthy individuals. This was a randomised, placebo-controlled and crossover study. Sixteen (n = 16) volunteers were randomised to receive placebo, curcumin (180 mg) tablets, fish oil (1.2 g long chain omega-3 polyunsaturated fatty acids) capsules and curcumin + fish oil prior to a standard meal on 4 test days separated by a week. Blood glucose, serum insulin and triglycerides were measured at intervals between 0-120 min. Difference between the treatments was measured using two-way repeated measures analysis of variance and pair-wise comparisons using Wilcoxon signed-rank or paired t-test as appropriate. Postprandial glucose concentrations were significantly lower in the curcumin (60.6%, P = 0.0007) and curcumin + fishoil group (51%, P = 0.002) groups at 60 min from baseline. Compared with placebo, area under the curve (AUC) for change in blood glucose concentration was reduced by curcumin (36%, P = 0.003) and curcumin + fishoil (30%, 0.004), but not fish oil alone (p = 0.105). Both curcumin (P = 0.01) and curcumin + fishoil (P = 0.03) treatments significantly lowered postprandial insulin (AUC) by 26% in comparison with placebo. Curcumin, but not fish oil, reduces postprandial glycaemic response and insulin demand for glucose control.
在当前的研究中，我们旨在评估姜黄素和/或鱼油单次剂量对健康个体餐后血糖参数的影响。这是一项随机、安慰剂对照和交叉研究。16 名志愿者（n=16）随机分为安慰剂组、姜黄素（180mg）片组、鱼油（1.2g 长链 ω-3 多不饱和脂肪酸）胶囊组和姜黄素+鱼油组，在 4 个测试日之前，每个测试日之间间隔一周，接受标准餐。在 0-120 分钟之间的间隔测量血糖、血清胰岛素和甘油三酯。使用双向重复测量方差分析测量处理之间的差异，并使用 Wilcoxon 符号秩或配对 t 检验进行适当的两两比较。与基线相比，姜黄素（60.6%，P=0.0007）和姜黄素+鱼油组（51%，P=0.002）在 60 分钟时餐后血糖浓度显著降低。与安慰剂相比，姜黄素（36%，P=0.003）和姜黄素+鱼油（30%，P=0.004）降低了血糖浓度变化的曲线下面积（AUC），但鱼油单独（p=0.105）没有。与安慰剂相比，姜黄素（P=0.01）和姜黄素+鱼油（P=0.03）治疗均显著降低了餐后胰岛素（AUC）的 26%。姜黄素而不是鱼油，可降低餐后血糖反应和胰岛素对葡萄糖控制的需求。
