Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Pharmacol Res. 2018 Oct;136:181-193. doi: 10.1016/j.phrs.2018.09.012. Epub 2018 Sep 13.
Diabetes mellitus is an extremely prevalent endocrine disease and a major global public health concern. Diabetic complications, such as retinopathy, nephropathy, neuropathy and cardiovascular disease, are common and majorly impact a patient's quality of life. Curcumin, the major active component of turmeric, possesses extensive known pharmacological properties, including anti-inflammatory, antioxidant, and antitumor effects. Increasing evidence suggests that curcumin may offer protection against diabetic complications. The current review focuses on the possible molecular targets and pathways involved in diabetic complications and, in particular, the multi-target approach of curcumin in attenuating diabetic nephropathy, retinopathy, and neuropathy.
糖尿病是一种极其普遍的内分泌疾病，也是一个全球性的主要公共卫生关注点。糖尿病并发症，如视网膜病变、肾病、神经病变和心血管疾病，很常见，严重影响患者的生活质量。姜黄素是姜黄的主要活性成分，具有广泛的已知药理学特性，包括抗炎、抗氧化和抗肿瘤作用。越来越多的证据表明，姜黄素可能对糖尿病并发症有保护作用。本综述重点介绍了糖尿病并发症涉及的可能的分子靶点和途径，特别是姜黄素在减轻糖尿病肾病、视网膜病变和神经病变方面的多靶点作用。
