Smeraldi E, Gambini O, Bellodi L, Sacchetti E, Vita A, di Rosa M, Macciardi F, Cazzullo C L
Psychiatry Res. 1987 Aug;21(4):293-301. doi: 10.1016/0165-1781(87)90012-6.
Smooth pursuit eye movements (SPEM) were examined in 67 schizophrenic patients and 101 control subjects. Our study confirms that eye tracking in schizophrenic patients is impaired compared to that in controls. The similar pattern of distribution of SPEM abnormalities in Italian patients as in ethnically different populations strengthens the hypothesis that these abnormalities may be a biological marker for schizophrenia. We also examined the relationship between SPEM abnormalities and the ventricle-brain ratio (VBR), which is also considered useful for differentiating schizophrenic subgroups. Our preliminary results indicate that there is an inverse correlation between abnormal SPEM performance and ventricular enlargement, suggesting that these abnormalities mark distinct subgroups of patients.
对67名精神分裂症患者和101名对照受试者进行了平稳跟踪眼球运动（SPEM）检查。我们的研究证实，与对照组相比，精神分裂症患者的眼球跟踪存在受损情况。意大利患者中SPEM异常的分布模式与种族不同的人群相似，这强化了以下假说：这些异常可能是精神分裂症的生物学标志物。我们还研究了SPEM异常与脑室脑比（VBR）之间的关系，VBR也被认为有助于区分精神分裂症亚组。我们的初步结果表明，SPEM异常表现与脑室扩大之间存在负相关，这表明这些异常标志着不同的患者亚组。
