Siever L J, van Kammen D P, Linnoila M, Alterman I, Hare T, Murphy D L
Biol Psychiatry. 1986 Oct;21(12):1167-74. doi: 10.1016/0006-3223(86)90223-4.
The accuracy of smooth pursuit eye movements (SPEMs) was evaluated electrooculographically in 14 medication-free schizophrenics. Concentrations of monoamine metabolites and gamma-amino-butyric acid (GABA) were measured in their cerebrospinal fluid (CSF). Ventricular-brain ratios (VBR) were determined by computed axial tomography (CT scan). Premorbid adjustment was evaluated by the Phillips Scale. The SPEMs of eight of the patients were reevaluated after 2 weeks of treatment with either prazosin or pimozide. No consistent significant correlations were found between SPEM accuracy and CSF metabolite concentrations, VBR, or premorbid adjustment. SPEM accuracy was not correlated with number of days off medication and was significantly correlated when measured before and during medication.
通过眼电图对14名未服用药物的精神分裂症患者的平稳跟踪眼球运动（SPEMs）准确性进行了评估。测量了他们脑脊液（CSF）中单胺代谢物和γ-氨基丁酸（GABA）的浓度。通过计算机断层扫描（CT扫描）测定脑室脑比率（VBR）。采用菲利普斯量表评估病前适应情况。其中8名患者在接受哌唑嗪或匹莫齐特治疗2周后对其SPEMs进行了重新评估。未发现SPEM准确性与CSF代谢物浓度、VBR或病前适应情况之间存在一致的显著相关性。SPEM准确性与停药天数无关，在用药前和用药期间测量时存在显著相关性。
