Ophthalmic Surg Lasers Imaging Retina. 2022 Jan;53(1):49-51. doi: 10.3928/23258160-20211209-02. Epub 2022 Jan 1.
This article reports a case of a 65-year-old woman with recalcitrant recurrent epiretinal membrane (ERM) treated with revision vitrectomy and membrane peeling followed by 12 weekly intravitreal methotrexate injections. Visual acuity and central macular thickness significantly improved, and no ERM recurrence developed 7 months after surgery. This case represents the first documented use of methotrexate to treat surgically resistant ERM reproliferation and indicates a potential for its use in cases that do not respond to standard treatment. .
本文报告了一例 65 岁女性复发性顽固型视网膜内界膜（ERM），采用玻璃体切割术联合膜剥除术治疗，随后每周玻璃体腔内注射甲氨蝶呤 12 次。视力和黄斑中心厚度明显改善，术后 7 个月无 ERM 复发。该病例代表了首例使用甲氨蝶呤治疗手术抵抗性 ERM 增殖的病例，并表明其在对标准治疗无反应的情况下可能具有一定的应用潜力。
