Bertrand D, Taron F, Manel J, Laxenaire M C
Ann Fr Anesth Reanim. 1987;6(4):289-92. doi: 10.1016/s0750-7658(87)80042-4.
Forty patients who where to undergo suspension laryngoscopy were randomly assigned to two groups, the first receiving 1 microgram . kg-1 fentanyl and a bolus of 2.5 mg . kg-1 propofol followed by 5 to 10 mg . kg-1 . h-1 propofol infusion, and the second 1 microgram . kg-1 fentanyl and 0.2 mg . kg-1 flunitrazepam with 8 mg . kg-1 propanidid in a bolus followed by 40 to 50 mg . kg-1 propanidid infusion. The following parameters were studied: length of apnoea, quality of anaesthesia, the time between stopping giving the anaesthetic and the moment when the patient opens the eyes, gives his name and date of birth, the heart rate, the systolic, diastolic and mean blood pressures, blood gases, before induction, during suspension and at stopping the infusion. Anaesthetic quality was the same for both protocols, and the variations of the haemodynamic parameters were very similar for both groups. Apnoea lasted twice as long with propofol as with the flunitrazepam-propanidid association (p less than 0.001), whereas recovery was twice as quick (p less than 0.001). This seemed to confirm that propofol is better indicated for this type of surgery than the previously used flunitrazepam-propanidid association.
40例拟行支撑喉镜检查的患者被随机分为两组，第一组接受1微克/千克芬太尼和2.5毫克/千克丙泊酚的单次推注，随后以5至10毫克/千克·小时的速度输注丙泊酚；第二组接受1微克/千克芬太尼和0.2毫克/千克氟硝西泮，单次推注8毫克/千克普尔安，随后以40至50毫克/千克·小时的速度输注普尔安。研究了以下参数：呼吸暂停时间、麻醉质量、停止给予麻醉药至患者睁眼、说出自己的姓名和出生日期的时间、心率、收缩压、舒张压和平均血压、诱导前、支撑喉镜检查期间及停止输注时的血气。两种方案的麻醉质量相同，两组血流动力学参数的变化非常相似。丙泊酚组的呼吸暂停时间是氟硝西泮-普尔安联合组的两倍（p<0.001），而恢复速度是其两倍（p<0.001）。这似乎证实，对于此类手术，丙泊酚比先前使用的氟硝西泮-普尔安联合用药更适用。
