Marcillon M, Mérot S, Rives E, Ghariani M, Gard J O, Raucoules M, Maestracci P
Ann Fr Anesth Reanim. 1987;6(4):285-8. doi: 10.1016/s0750-7658(87)80041-2.
The properties of propofol in emulsion given by continuous intravenous infusion to spontaneously breathing patients have been well studied. Thirty randomized voluntary premedicated patients undergoing dental extraction were anaesthetized with propofol (2.5 mg X kg-1 IVD, and 9 mg X kg-1 X h-1) or with propanidid (9 mg X kg-1 IVD, and 60 mg X kg-1 X h-1), supplemented with nitrous oxide in oxygen and fentanyl. Induction, maintenance and recovery times had the same characteristics. Highly significant differences occurred between the two groups regarding the increase in heart rate, apnoea and recovery time. This study showed that propofol was an eminently suitable agent for continuous intravenous anaesthesia in spontaneously breathing patients for dental surgery.
对自主呼吸患者持续静脉输注丙泊酚乳剂的特性已进行了充分研究。30例接受牙科拔牙手术且已接受术前用药的随机自愿患者，分别用丙泊酚（静脉注射2.5mg/kg，每小时9mg/kg）或丙泮尼地（静脉注射9mg/kg，每小时60mg/kg）麻醉，并补充氧化亚氮和芬太尼。诱导、维持和恢复时间具有相同特征。两组在心率增加、呼吸暂停和恢复时间方面存在高度显著差异。本研究表明，丙泊酚是用于牙科手术自主呼吸患者持续静脉麻醉的极为合适的药物。
