定量超短 TE MR 成像中的脂肪饱和效应。
On the fat saturation effect in quantitative ultrashort TE MR imaging.
机构信息
Department of Medical Imaging, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Department of Radiology, University of California, San Diego, California, USA.
出版信息
Magn Reson Med. 2022 May;87(5):2388-2397. doi: 10.1002/mrm.29149. Epub 2022 Jan 5.
PURPOSE
To investigate the effect of fat saturation (FatSat) on quantitative UTE imaging of variable knee tissues on a 3T scanner.
METHODS
Three quantitative UTE imaging techniques, including the UTE multi-echo sequence for measurement, the adiabatic T prepared UTE sequence for T measurement, and the magnetization transfer (MT)-prepared UTE sequence for MT ratio (MTR) and macromolecular proton fraction (MMF) measurements were used in this study. Twelve samples of cartilage and twelve samples of meniscus, as well as six whole knee cadaveric specimens, were imaged with the three above-mentioned UTE sequences with and without FatSat. The difference, correlation, and agreement between the UTE measurements with and without FatSat were calculated to investigate the effects of FatSat on quantification.
RESULTS
Fat was well-suppressed using all three UTE sequences when FatSat was deployed. For the small sample study, the quantification difference ratio (QDR) values of all the measured biomarkers ranged from 0.7% to 12.6%, whereas for the whole knee joint specimen study, the QDR values ranged from 0.2% to 12.0%. Except for T in muscle and MMF in meniscus (p > 0.05), most of the measurements showed statistical differences for T , MTR, and MMF (p < 0.05) between FatSat and non-FatSat scans. Most of the measurements for showed no significant differences (p > 0.05). Strong correlations were found for all the biomarkers between measurements with and without FatSat.
CONCLUSION
The UTE biomarkers showed good correlation and agreement with some slight differences between the scans with and without FatSat.
目的
探究在 3T 扫描仪上使用脂肪饱和（FatSat）对可变膝关节组织的定量 UT 成像的影响。
方法
本研究使用了三种定量 UT 成像技术，包括用于测量的 UT 多回波序列、用于 T 测量的绝热 T 准备 UT 序列以及用于 MT 比（MTR）和大分子质子分数（MMF）测量的磁化传递（MT）准备 UT 序列。对软骨和半月板的 12 个样本以及 6 个全膝关节尸体标本，使用上述三种 UT 序列分别进行了有和没有 FatSat 的成像。计算了有和没有 FatSat 的 UT 测量之间的差异、相关性和一致性，以研究 FatSat 对定量的影响。
结果
使用所有三种 UT 序列时，FatSat 可很好地抑制脂肪。对于小样本研究，所有测量生物标志物的定量差异比（QDR）值范围为 0.7%至 12.6%，而对于整个膝关节标本研究，QDR 值范围为 0.2%至 12.0%。除了肌肉中的 T 和半月板中的 MMF（p>0.05）之外，大多数测量结果在 FatSat 和非 FatSat 扫描之间在 T、MTR 和 MMF 方面显示出统计学差异（p<0.05）。大多数测量结果在 方面没有显著差异（p>0.05）。所有生物标志物的测量结果在有和没有 FatSat 的情况下均显示出良好的相关性和一致性。
结论
UT 生物标志物在有和没有 FatSat 的扫描之间具有良好的相关性和一致性，但存在一些微小差异。
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