School of Medicine, Guangxi University, Nanning, People's Republic of China.
Institute of Gastrointestinal Oncology, School of Medicine, Xiamen University, Xiamen, People's Republic of China.
Biotechnol Appl Biochem. 2022 Feb;69(1):190-197. doi: 10.1002/bab.2096. Epub 2021 Jan 21.
Ferroptosis is a regulated cell death pathway based on the deposition of lipid-based reactive oxygen species (L-ROS) in the presence of iron ions. The term was first coined in 2012 by Dixon. Decreased glutathione (GSH) synthesis and low glutathione-dependent antioxidant peroxidase 4 (GPX4) activity are the major causes of ferroptosis. Sensitivity to ferroptosis for example in tumor cells may be further enhanced by high cellular iron concentrations and/or high p53 levels. Therefore, driving ferroptosis in tumor cells could be a new way to treat tumors. Thus far, natural products have played considerable roles in antitumor research and treatment, and some drugs, such as paclitaxel, have proven beneficial in many cancer patients. According to current research, natural products can induce ferroptosis when used alone or in conjunction with other cancer therapies. This review mainly elaborates the main mechanism of ferroptosis and the regulating effects of some natural products on ferroptosis, aiming to create a new space for the research and development of novel anticancer drugs.
铁死亡是一种依赖于铁离子的脂质活性氧（L-ROS）沉积的调节性细胞死亡途径。该术语于 2012 年由 Dixon 首次提出。谷胱甘肽（GSH）合成减少和谷胱甘肽依赖性抗氧化过氧化物酶 4（GPX4）活性降低是铁死亡的主要原因。例如，肿瘤细胞对铁死亡的敏感性可能进一步被高细胞铁浓度和/或高 p53 水平增强。因此，诱导肿瘤细胞铁死亡可能是治疗肿瘤的一种新方法。到目前为止，天然产物在抗肿瘤研究和治疗中发挥了重要作用，一些药物，如紫杉醇，已被证明对许多癌症患者有益。根据目前的研究，天然产物在单独使用或与其他癌症治疗方法联合使用时可以诱导铁死亡。本综述主要阐述了铁死亡的主要机制和一些天然产物对铁死亡的调节作用，旨在为新型抗癌药物的研究和开发创造新的空间。
