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银冷杉()木材水提物与乳酸菌的相互作用。

Interaction between silver fir () wood water extract and lactobacilli.

机构信息

Department of Biotechnology, Jožef Stefan Institute, University of Ljubljana, Slovenia; Faculty of Pharmacy, University of Ljubljana, Slovenia;, Email:

Faculty of Pharmacy, University of Ljubljana, Slovenia.

出版信息

Pharmazie. 2021 Dec 5;76(12):614-617. doi: 10.1691/ph.2021.1794.

Abstract

Water extract from silver fir () wood represents a rich source of lignans and other phenols that are effective in different pathological conditions, such as diabetes, cardiovascular diseases and psoriasis. Its interaction with the gastrointestinal environment is crucial when the extract is orally administered. In this study we tested the interaction between water extract of silver fir wood and ten different species that are found in the gastrointestinal tract, vagina or are used in food industry. We tested both ways of interaction: 1) the bacterial influence on the chemical composition of the extract and 2) influence of the extract on the bacterial growth. We demonstrated that the extract is compatible with all of the bacteria and does not impair their growth. Furthermore the extract acted as a prebiotic for some bacteria including: , , , , and , suggesting that the compounds in the extract can stimulate their growth. However, the ten lactobacilli did not show any chemical changes in lignan metabolism and the production of enterodiol and enterolactone, which are considered the final metabolic products of lignans and are produced by different gut bacteria. This study indicates that the silver fir wood extract is nutritious for some bacteria and can be used as a prebiotic.

摘要

水从银冷杉()木材提取物代表了一个丰富的木质素和其他酚类化合物,这些化合物在不同的病理条件下有效,如糖尿病,心血管疾病和牛皮癣。其与胃肠道环境的相互作用是至关重要的,当提取物口服给药。在这项研究中,我们测试了水提取物与胃肠道、阴道中发现的十种不同的物种之间的相互作用,或用于食品工业。我们测试了两种相互作用的方式:1)细菌对提取物化学成分的影响,2)提取物对细菌生长的影响。我们证明,提取物与所有细菌都兼容,并且不会损害它们的生长。此外,提取物对一些细菌表现出益生元的作用,包括:、、、、、、,这表明提取物中的化合物可以刺激它们的生长。然而,十种乳杆菌在木质素代谢和肠二醇和肠内酯的产生方面没有显示出任何化学变化,肠二醇和肠内酯被认为是木质素的最终代谢产物,由不同的肠道细菌产生。这项研究表明,银冷杉木材提取物对一些细菌有营养,可以用作益生元。

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