Wan Chuanqi, Zhu Chen, Jin Gulei, Zhu Min, Hua Junyi, He Yuzhou
The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Guhe Information Technology Company, Hangzhou, China.
Evid Based Complement Alternat Med. 2021 Dec 27;2021:7195082. doi: 10.1155/2021/7195082. eCollection 2021.
Cardiovascular and cerebrovascular diseases are characterized by high rates of morbidity and mortality. Microbiota is closely associated with cardiovascular disease. We aimed to comprehensively analyze the microbiotas of 300 healthy controls, 300 patients with high blood pressure (HBP), and 300 patients with coronary heart disease (CHD). The results indicated no significant difference in microbiota diversity among the three groups ( > 0.05). However, differences in microbiota richness among the three groups were significant ( < 0.05). Bacteroidetes and Bacteroidia were the dominant bacteria in the CHD group, Enterobacteriales and in the HBP group, and Acidaminococcaceae and in the healthy control group. The prediction results of the random forest model indicated that the population with CHD displayed prominent features with high sensitivity, indicating that microbiota detection might become a novel clinical indicator to predict and monitor the risk of cardiovascular events. The prediction of microbiota function suggested differences in oxygen supply and chronic inflammation between populations with HBP/CHD and healthy populations. Although there is no difference in gut microbiota diversity among the three groups, each group has its dominant microbiota in terms of richness.
心血管疾病具有高发病率和高死亡率的特点。微生物群与心血管疾病密切相关。我们旨在全面分析300名健康对照者、300名高血压患者（HBP）和300名冠心病患者（CHD）的微生物群。结果表明，三组之间的微生物群多样性无显著差异（>0.05）。然而，三组之间的微生物群丰富度存在显著差异（<0.05）。拟杆菌门和拟杆菌纲是冠心病组中的优势菌，肠杆菌目是高血压组中的优势菌，而健康对照组中的优势菌是氨基酸球菌科。随机森林模型的预测结果表明，冠心病患者群体具有高敏感性的显著特征，这表明微生物群检测可能成为预测和监测心血管事件风险的一种新型临床指标。微生物群功能预测表明，高血压/冠心病患者群体与健康群体在氧气供应和慢性炎症方面存在差异。尽管三组之间肠道微生物群多样性没有差异，但就丰富度而言，每组都有其优势微生物群。
