The State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, People's Republic of China.
High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Drug Ability, Key Laboratory of Optimal Utilization of Natural Medicinal Resources, Guizhou Medical University, Guiyang, People's Republic of China.
Nat Prod Res. 2022 Nov;36(22):5740-5746. doi: 10.1080/14786419.2021.2023866. Epub 2022 Jan 6.
A new kavalactone, 4'-hydroxyl dihydro-5, 6-dehydrokavain () was isolated from the petroleum ether partition of leaves of (Pers.) Burtt. et Smith, together with four known kavalactone dimers, -1,-3--(4-methoxy-2-oxopyran-6-yl)--2,-4-diphenyl cyclobutene (), aniba dimer A (), aniba dimer C (), 6,6'-(3,4-diphenylcyclobutane-1,2-diyl)(4-methoxy-2-pyran-2-one (). The structure of compound was characterized by its MS, 1D-NMR, and 2D-NMR data, and the structures of the known compounds were determined by comparison of their spectroscopic data with those reported by the literatures. The obtained compounds were evaluated for their protective activities on human umbilical vein endothelial cells (HUVECs) damaged by high glucose (35 mM, cell viability at 70.10%). Compounds and could increase the cell viability at the concentration of 12.5 μΜ (83.12%) and 25 μΜ (75.02%), whereas at the concentration of 12.5 μΜ, compounds , , and didn't reverse cell damage (cell viability at 38.58%, 54.80% and 58.16%).
一种新的卡瓦内酯，4'-羟基二氢-5,6-去氢卡瓦内酯 ()，从 （Pers.）Burtt. 和 Smith 的叶子的石油醚部分分离出来，与四种已知的卡瓦内酯二聚体，-1,-3--(4-甲氧基-2-氧代吡喃-6-基)--2,-4-二苯基环丁烯 (), aniba 二聚体 A (), aniba 二聚体 C (), 6,6'-(3,4-二苯基环丁烷-1,2-二基)(4-甲氧基-2-吡喃-2-酮 ()一起分离出来。化合物的结构通过其 MS、1D-NMR 和 2D-NMR 数据进行了表征，并且已知化合物的结构通过与文献报道的光谱数据进行比较来确定。对获得的化合物进行了评价，以评估它们对高葡萄糖（35 mM，细胞活力为 70.10%）损伤的人脐静脉内皮细胞（HUVEC）的保护活性。化合物 和 在 12.5 μM 的浓度下可以增加细胞活力（83.12%）和 25 μM（75.02%），而在 12.5 μM 的浓度下，化合物 、 、和 不能逆转细胞损伤（细胞活力分别为 38.58%、54.80%和 58.16%）。
