脑室内窥脑发育和疾病。
Brain ventricles as windows into brain development and disease.
机构信息
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; Medical Scientist Training Program, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
出版信息
Neuron. 2022 Jan 5;110(1):12-15. doi: 10.1016/j.neuron.2021.12.009.
Abstract
Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.
摘要
脑室内充满液体的扩张（脑室扩大）是脑积水的特征，在自闭症和精神分裂症中经常见到。最近的研究表明，对先天性脑积水的基因组研究可能会意外地为揭示神经干细胞调控、人类大脑皮质发育和神经精神疾病发病机制的见解提供肥沃的土壤。
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