School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, Wuhan, 430074, People's Republic of China.
Phytochemistry. 2022 Apr;196:113081. doi: 10.1016/j.phytochem.2021.113081. Epub 2022 Jan 3.
Seven previously undescribed cadinane sesquiterpenoids, albocinnamins A‒G, were isolated from the fungus Antrodiella albocinnamomea. Their structures with absolute configurations were elucidated on the basis of extensive spectroscopic methods, as well as single crystal X-ray diffraction. Cadinane sesquiterpenoids were reported from A. albocinnamomea for the first time. All of these sesquiterpenoids possess an unusual ether ring with minor modifications. Albocinnamins D and G showed certain inhibitory activities against nitric oxide production in LPS-activated RAW264.7 macrophages with IC values of 26.1 and 19.2 μM, respectively.
从真菌黄白肉齿菌（Antrodiella albocinnamomea）中分离得到了 7 种以前未描述的卡丹烷倍半萜，命名为 albocinnamins A-G。基于广泛的光谱方法以及单晶 X 射线衍射，确定了它们的结构和绝对构型。这是首次从黄白肉齿菌中报道的卡丹烷倍半萜。所有这些倍半萜都含有一个不常见的醚环，有轻微的修饰。albocinnamins D 和 G 对 LPS 激活的 RAW264.7 巨噬细胞中一氧化氮的产生具有一定的抑制活性，IC 值分别为 26.1 和 19.2 μM。
