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从……分离出的一种内生真菌中得到的四种新的高度氧化的桉叶烷倍半萜

Four New Highly Oxygenated Eremophilane Sesquiterpenes from an Endophytic Fungus Isolated from .

作者信息

Ai Hong-Lian, Lv Xiao, Ye Ke, Wang Meng-Xi, Huang Rong, Shi Bao-Bao, Li Zheng-Hui

机构信息

School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, China.

出版信息

J Fungi (Basel). 2022 May 8;8(5):492. doi: 10.3390/jof8050492.

DOI:10.3390/jof8050492
PMID:35628748
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9146970/
Abstract

Four new eremophilane-type sesquiterpenes, boeremialanes A-D (-) were obtained from solid substrate cultures of (Didymellaceae), an endophytic fungus isolated from (Liliaceae). Boeremialanes A-C (-) are highly oxygenated eremophilanes with a benzoate unit attached at the C-13 position and are rarely found in nature. Their structures and absolute configurations were determined by extensive spectroscopic methods, electronic circular dichroism (ECD), and nuclear magnetic resonance (NMR) calculations with DP4+ analysis. Boeremialane D () potently inhibited nitric oxide production in lipopolysaccharide-treated RAW264.7 macrophages with an IC of 8.62 μM and was more potent than the positive control, pyrrolidinedithiocarbamate (IC = 23.1 μM).

摘要

从从百合科植物中分离出的内生真菌（双隔孢属，Didymellaceae）的固体基质培养物中获得了四种新的艾里莫芬烷型倍半萜，即波勒米烷A-D（-）。波勒米烷A-C（-）是高度氧化的艾里莫芬烷，在C-13位连接有一个苯甲酸酯单元，在自然界中很少见。通过广泛的光谱方法、电子圆二色性（ECD）和带有DP4 +分析的核磁共振（NMR）计算确定了它们的结构和绝对构型。波勒米烷D（）在脂多糖处理的RAW264.7巨噬细胞中有效抑制一氧化氮的产生，IC为8.62 μM，比阳性对照吡咯烷二硫代氨基甲酸盐（IC = 23.1 μM）更有效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/bdfd37b401be/jof-08-00492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/7cea9846f188/jof-08-00492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/9fc36068bcc0/jof-08-00492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/57026ec8e753/jof-08-00492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/4aa75c047b60/jof-08-00492-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/7e47d98268e1/jof-08-00492-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/bdfd37b401be/jof-08-00492-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/7cea9846f188/jof-08-00492-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/9fc36068bcc0/jof-08-00492-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/57026ec8e753/jof-08-00492-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/4aa75c047b60/jof-08-00492-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/7e47d98268e1/jof-08-00492-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bafa/9146970/bdfd37b401be/jof-08-00492-g006.jpg

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