Laboratory of Biotechnology and Plant Improvement, Centre of Biotechnology of Sfax (CBS), University of Sfax, Tunisia.
Centro de Biotecnología y Genómica de Plantas (CBGP), Universidad Politécnica de Madrid (UPM), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Spain; Departamento de Biotecnología-Biología Vegetal, Escuela Técnica Superior de Ingeniería Agronómica, Alimentaria y de Biosistemas, Universidad Politécnica de Madrid (UPM), Spain.
Plant Physiol Biochem. 2022 Jan 15;171:115-127. doi: 10.1016/j.plaphy.2021.12.026. Epub 2021 Dec 30.
Plant non-specific lipid transfer proteins (nsLTPs) are usually defined as small, basic proteins, with a wide distribution in all orders of higher plants. Structurally, nsLTPs contain a conserved motif of eight cysteines, linked by four disulphide bonds, and a hydrophobic cavity in which the ligand is housed. This structure confers stability and enhances the ability to bind and transport a variety of hydrophobic molecules. Their highly conserved structural resemblance but low sequence identity reflects the wide variety of ligands they can carry, as well as the broad biological functions to which they are linked to, such as membrane stabilization, cell wall organization and signal transduction. In addition, they have also been described as essential in resistance to biotic and abiotic stresses, plant growth and development, seed development, and germination. Hence, there is growing interest in this family of proteins for their critical roles in plant development and for the many unresolved questions that need to be clarified, regarding their subcellular localization, transfer capacity, expression profile, biological function, and evolution.
植物非特异性脂质转移蛋白（nsLTPs）通常被定义为小的碱性蛋白，在所有高等植物的目中广泛分布。在结构上，nsLTPs 含有一个保守的八个半胱氨酸模体，通过四个二硫键连接，并形成一个容纳配体的疏水性腔。这种结构赋予了它们稳定性，并增强了结合和运输各种疏水分子的能力。它们高度保守的结构相似性但低序列同一性反映了它们可以携带的各种配体，以及它们与之相关的广泛的生物学功能，例如膜稳定、细胞壁组织和信号转导。此外，它们还被描述为对生物和非生物胁迫、植物生长和发育、种子发育和萌发至关重要。因此，人们对这些蛋白质家族的兴趣日益浓厚，因为它们在植物发育中具有重要作用，并且有许多尚未解决的问题需要澄清，例如它们的亚细胞定位、转移能力、表达谱、生物学功能和进化。
