Helminen Olli, Kauppila Joonas H, Saviaro Henna, Yannopoulos Fredrik, Meriläinen Sanna, Koivukangas Vesa, Huhta Heikki, Mrena Johanna, Saarnio Juha, Sihvo Eero
Surgery Research Unit, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.
Department of Surgery, Central Finland Central Hospital, Jyväskylä, Finland.
J Thorac Dis. 2021 Nov;13(11):6261-6271. doi: 10.21037/jtd-21-1063.
Minimally invasive esophagectomy (MIE) is a complex procedure with learning associated morbidity. The aim was to evaluate the learning curve for MIE focusing on short-term outcomes in two settings: (I) experienced MIE surgeon in new hospital (Hospital 1); (II) surgeons experienced with open esophagectomy and minimally invasive surrogate surgery (Hospital 2).
In Hospital 1 and Hospital 2, on intent-to-treat basis number of MIEs were 132 and 57, respectively. The primary outcomes were major complications and anastomosis leaks. Secondary outcomes were operative time, blood loss, lymph node yield, hospital stay and 1-year mortality. Length of learning curves were analyzed with risk-adjusted cumulative sum (RA-CUSUM) method.
In Hospital 1, major complication and anastomosis leak rates were 9.8% and 4.5%, 22.8% and 12.3% in Hospital 2, respectively. In Hospital 1, complication and leak rates remained stable. In Hospital 2, improvement occurred after 34 cases in major complications and 29 cases in leaks. Of secondary outcomes, improvements were seen in Hospital 1 in operative time after 61, blood loss after 86, lymph node yield after 52, hospital stay after 19 and 1-year mortality after 24 cases. In Hospital 2, improvement occurred in operative time after 30, blood loss after 15, lymph node yield after 45, hospital stay after 50 and 1-year mortality after 15 cases.
According to this study, learning phase of the individual surgeon determines the outcomes of MIE, not the institutional learning phase.
微创食管切除术(MIE)是一项复杂的手术,存在与学习相关的发病率。目的是评估MIE的学习曲线,重点关注两种情况下的短期结果:(I)在新医院(医院1)的经验丰富的MIE外科医生;(II)有开放食管切除术和微创替代手术经验的外科医生(医院2)。
在医院1和医院2,按意向性治疗分析,MIE的例数分别为132例和57例。主要结局是严重并发症和吻合口漏。次要结局是手术时间、失血量、淋巴结收获量、住院时间和1年死亡率。采用风险调整累积和(RA-CUSUM)方法分析学习曲线的长度。
在医院1,严重并发症和吻合口漏发生率分别为9.8%和4.5%,在医院2分别为22.8%和12.3%。在医院1,并发症和漏发生率保持稳定。在医院2,严重并发症在34例后、漏在29例后有所改善。在次要结局方面,医院1在61例后手术时间、86例后失血量、52例后淋巴结收获量、19例后住院时间和24例后1年死亡率方面有所改善。在医院2,30例后手术时间、15例后失血量、45例后淋巴结收获量、50例后住院时间和15例后1年死亡率方面有所改善。
根据本研究,个体外科医生的学习阶段决定了MIE的结果,而非机构学习阶段。