Musielak Marika, Graczyk Kinga, Szweda Hubert, Kruszyna-Mochalska Marta, Suchorska Wiktoria
Department of Electroradiology, Poznan University of Medical Sciences, Poznań, Poland.
Radiobiology Laboratory, Department of Medical Physics, Greater Poland Cancer Centre, Poznań, Poland.
Rep Pract Oncol Radiother. 2021 Dec 30;26(6):1051-1056. doi: 10.5603/RPOR.a2021.0134. eCollection 2021.
Due to the lack of selectivity of ionizing radiation between normal and cancer cells, it is important to improve the existing radiation patterns. Lowering the risk of cancer recurrence and comfort during treatment are priorities in radiotherapy.
In the experiment we used dose verification to determine the irradiation time calculated by a treatment planning system for 6XFFF and 10XFFF beams. Cells cultured under standard conditions were irradiated with a dose of 2 Gy at different beam rates 400 MU/min, 600 MU/min, 800 MU/min, 1000 MU/min, 1400 MU/min, 1600 MU/min and 2400 MU/min using 6XFFF, 10XFFF and 6XFF beams.
The experiment was aimed at comparing the biological response of normal prostate cells after clinically applied radiation patterns. No statistically significant differences in the cellular response were observed. The wide range of beam rates as well as the beam profiles did not significantly affect cell proliferation.
High beam rates, without significantly affecting the clonogenic capacity of cells, have an impact on the quality of patient's treatment. With the increasing beam rate the irradiation time is shortened, which has an important impact on patients' health. This experiment can have a practical significance.
由于电离辐射对正常细胞和癌细胞缺乏选择性，改进现有的放射模式很重要。降低癌症复发风险和治疗期间的舒适度是放射治疗的首要任务。
在实验中，我们使用剂量验证来确定治疗计划系统计算的6XFFF和10XFFF射束的照射时间。在标准条件下培养的细胞，使用6XFFF、10XFFF和6XFF射束，以400 MU/分钟、600 MU/分钟、800 MU/分钟、1000 MU/分钟、1400 MU/分钟、1600 MU/分钟和2400 MU/分钟的不同射束速率照射2 Gy的剂量。
该实验旨在比较临床应用放射模式后正常前列腺细胞的生物学反应。未观察到细胞反应有统计学上的显著差异。广泛的射束速率以及射束轮廓对细胞增殖没有显著影响。
高射束速率在不显著影响细胞克隆形成能力的情况下，对患者的治疗质量有影响。随着射束速率的增加，照射时间缩短，这对患者健康有重要影响。该实验具有实际意义。
